How Hydras get their heads

The expression of Wnt signaling proteins in the head organizer of Hydra, a freshwater polyp, suggests that Wnt was central in the evolution of axial differentiation.

By | September 22, 2000

In the 14 September Nature Hobmayer et al. find that Wnt signaling proteins are expressed in the head organizer of Hydra, a freshwater polyp, suggesting that Wnt was central in the evolution of axial differentiation in early multicellular animals (Nature 2000, 407:186-189). Hobmayer et al. isolate a number of Wnt pathway proteins from Hydra and find that their protein-interacting domains are well conserved when compared with Wnt pathway proteins from metazoans. Expression of Hydra β-catenin in frog embryos duplicates the embryos' head structures, and Wnt signaling proteins are turned on in newly budded or regenerating Hydra heads. The previous candidates for ancient anterior patterners were the Hox genes; determining how Hox function and Wnt function relate to each other will require further study.

Popular Now

  1. Broad Wins CRISPR Patent Interference Case
    Daily News Broad Wins CRISPR Patent Interference Case

    The USPTO’s Patent Trial and Appeal Board has ruled in favor of the Broad Institute of MIT and Harvard retaining intellectual property rights covered by its patents for CRISPR gene-editing technology.

  2. Henrietta Lacks’s Family Seeks Compensation
  3. Can Plants Learn to Associate Stimuli with Reward?
  4. Humans Never Stopped Evolving
    Features Humans Never Stopped Evolving

    The emergence of blood abnormalities, an adult ability to digest milk, and changes in our physical appearance point to the continued evolution of the human race.

Business Birmingham