SNPs pair up in asthma pharmacogenetics

Combinations of SNPs within the beta2-adrenergic receptor gene affect the response to asthma drugs.

By | September 25, 2000

Many believe that single nucleotide polymorphisms (SNPs) will prove to be powerful tools as predictive pharmacogenetic loci. In the September 12 Proceedings of the National Academy of Sciences, Drysdale et al. examined the functional significance of SNPs in the 5' upstream and ORF regions of the β2-adrenergic receptor (β2-AR) gene (Proc Natl Acad Sci USA 2000, 97:10483-10488 [abstract]) The β2-ARs are G-protein coupled receptors that can cause muscle relaxation and bronchodilation. Beta-blocker agonists are used as drugs to treat bronchospasms in asthma patients. Drysdale et al. characterized 13 SNPs in the β2-AR gene that were grouped into 12 distinct combinations (haplotypes). They analyzed a group of 121 asthmatics and their response to the beta-blocker albuterol. Pairs of haplotypes were significantly related to drug responsiveness, whereas single SNP haplotypes were not. Furthermore, in vitro transfection experiments showed that SNP haplotypes affect β2-AR expression and receptor density. These results caution against the predictive utility of randomly chosen individual SNP loci, and emphasize the advantage of analyzing multiple SNP combinations simultaneously.

Popular Now

  1. Running on Empty
    Features Running on Empty

    Regularly taking breaks from eating—for hours or days—can trigger changes both expected, such as in metabolic dynamics and inflammation, and surprising, as in immune system function and cancer progression.

  2. Gut Feeling
    Daily News Gut Feeling

    Sensory cells of the mouse intestine let the brain know if certain compounds are present by speaking directly to gut neurons via serotonin.

  3. Athletes’ Microbiomes Differ from Nonathletes
  4. Government Nixes Teaching Evolution in Turkish Schools
AAAS