Gene expression profiles of mouse brains
Inbred mouse strains have been shown to vary considerably in neurobehavioral testing. In the September 26 Proceedings of the National Academy of Science, Sandberg et al. describe the first use of DNA microarrays to determine the genetics events that might explain these phenotypic differences (Proc Natl Acad Sci USA 2000, 97:11038-11043). They compared two common inbred mouse strains (C57BL/6 and 129SvEv) by examining the expression profiles of over 10,000 genes in six different brain regions.