Selective remodelling

DNA-binding transcription factors can target the SWI/SNF chromatin remodelling complex to specific nucleosome sites.

By | October 25, 2000

The regulation of gene expression is achieved by the functional interplay between factors that can remodel compacted chromatin and transcription factors that bind to specific DNA sequences. In the October Genes and Development Kadam et al. use recombinant proteins to show a direct physical interaction between transcription factors and the remodelling machinery in vitro (Genes Dev 2000, 14:2441-2451). Transcriptional regulation of the human β-globin promoter requires both the ELKF erythroid transcription factor and the SWI/SNF chromatin remodelling complex. Kadam et al. show that the ELKF zinc finger DNA-binding domain interacts with two SWI/SNF subunits (BAF155 and the ATPase BRG1). This interaction is necessary and sufficient for targeted chromatin remodelling and transcriptional activation of the β-globin promoter. The selectivity of the SWI/SNF-zinc finger interaction offers a mechanism for regulating specific subsets of genes by the chromatin remodelling machinery.

Popular Now

  1. Top 10 Innovations 2016
    Features Top 10 Innovations 2016

    This year’s list of winners celebrates both large leaps and small (but important) steps in life science technology.

  2. Gut Microbes Linked to Neurodegenerative Disease
  3. Pubic Hair Grooming Linked to STI Risk
    The Nutshell Pubic Hair Grooming Linked to STI Risk

    Observational study suggests pubic hair grooming correlates with heightened risk of acquiring sexually transmitted infections, although causation remains unclear.

  4. Naive T Cells Find Homes in Lymphoid Tissue
Rockland