Becoming a worm

Sequencing of the worm genome has allowed Hill et al. to design oligonucleotide arrays representing 18,791 (98%) of the predicted worm open reading frames (ORFs). In the 27 October Science, they report the use of these arrays to analyze transcripts from six developmentally staged worm populations from eggs to adults (Science 2000, 290:809-812).

By | October 31, 2000

Sequencing of the worm genome has allowed Hill et al. to design oligonucleotide arrays representing 18,791 (98%) of the predicted worm open reading frames (ORFs). In the 27 October Science, they report the use of these arrays to analyze transcripts from six developmentally staged worm populations from eggs to adults (Science 2000, 290:809-812). Only 56% of the ORFs are detected at least once, suggesting that others are missed because they are expressed at very low levels in specific tissues or under specific conditions. Aging worms show transcriptional correlates of impaired muscle function, reduced metabolic activity and extracellular matrix defects. During development, expression of genes specific to worms becomes more predominant, at the expense of expression of genes that are evolutionarily conserved.

Popular Now

  1. Top 10 Innovations 2016
    Features Top 10 Innovations 2016

    This year’s list of winners celebrates both large leaps and small (but important) steps in life science technology.

  2. Gut Microbes Linked to Neurodegenerative Disease
  3. Pubic Hair Grooming Linked to STI Risk
    The Nutshell Pubic Hair Grooming Linked to STI Risk

    Observational study suggests pubic hair grooming correlates with heightened risk of acquiring sexually transmitted infections, although causation remains unclear.

  4. Naive T Cells Find Homes in Lymphoid Tissue
Rockland