Malaria's dangerous neighborhood

The var genes of the malaria parasite Plasmodium falciparum encode the major variable parasite protein and are expressed in a mutually exclusive manner at the surface of an infected red blood cell. In the 26 October Nature, Freitas-Junior et al. report that Plasmodium uses nuclear architecture in a pathogen survival strategy (Nature 2000, 407:1018-1022). The sub-telomeric regions that contain the var genes are clustered together at the nuclear periphery, apparently allowing recombination at freq

By | October 31, 2000

The var genes of the malaria parasite Plasmodium falciparum encode the major variable parasite protein and are expressed in a mutually exclusive manner at the surface of an infected red blood cell. In the 26 October Nature, Freitas-Junior et al. report that Plasmodium uses nuclear architecture in a pathogen survival strategy (Nature 2000, 407:1018-1022). The sub-telomeric regions that contain the var genes are clustered together at the nuclear periphery, apparently allowing recombination at frequencies much higher than those expected from homologous crossover events alone.

Popular Now

  1. Major German Universities Cancel Elsevier Contracts
  2. Grass Routes
    Features Grass Routes

    Researchers are discovering a suite of new locations and functions of endocannabinoid receptors that play roles in sickness and in health.

  3. Studies Retracted After UCLA Investigation
  4. Trump Nominates Sam Clovis to Lead USDA Research
AAAS