Antibiotic treatment for infections of
They identified 628 patients, aged 35 to 75, admitted with a first hospitalization for MI, studied their drug history, and compared them to 1615 matched controls. Only intake of high doses of fluoroquinolones was significantly associated with a lower risk of acute myocardial infarction. For those who took more than one course of fluoroquinolones, the odds ratio was 0.12 (95% CI, 0.02-0.94). For all other antibiotics, in particular tetracyclines and macrolides, no significant association was observed.
The authors hypothesize the negative association of fluoroquinolones with MI may be mediated via their nonbacterial inhibitory actions, which may prevent calcification in the later stages of plaque formation.