Cycling surprises

Array analysis of dividing cells has been tackled for yeast, but in the January Nature Genetics Cho et al. present the first large-scale analysis in human cells (Nat Genet 2001, 27:48-54). They identify 731 of 40,000 human genes and expressed sequence tags (ESTs) as being cell cycle regulated in primary fibroblasts, and use a functional classification system to identify coordinate regulation of pathways. Notable surprises include upregulation of motility-related genes in G2 (perhaps to prepare d

By | January 5, 2001

Array analysis of dividing cells has been tackled for yeast, but in the January Nature Genetics Cho et al. present the first large-scale analysis in human cells (Nat Genet 2001, 27:48-54). They identify 731 of 40,000 human genes and expressed sequence tags (ESTs) as being cell cycle regulated in primary fibroblasts, and use a functional classification system to identify coordinate regulation of pathways. Notable surprises include upregulation of motility-related genes in G2 (perhaps to prepare daughter cells for migration away from each other), and of extracellular matrix-associated genes in M (possibly to enhance the re-establishment of cell-cell contact and communication after mitosis).

Popular Now

  1. Largest Human Genetic Variation Repository Yet
  2. The Neanderthal in the Mirror
    Reading Frames The Neanderthal in the Mirror

    Our evolutionary cousin is no longer a blundering caveman. Recent research has painted a picture of a human ancestor with culture, art, and advanced cognitive skills.

  3. Student Alleges His Team Didn’t Earn CRISPR Patent
  4. Zika Infects Adult Neural Progenitors Too
RayBiotech