Advertisement

How melanomas avoid apoptosis

Many cancers become resistant to chemotherapeutic drugs thanks to loss of the p53 protein, which promotes cell cycle arrest and apoptosis in response to certain drugs. Metastatic melanomas are unusual in that, despite their chemoresistance, they retain functional p53. In the January 11 Nature, Soengas et al. find that these melanomas still lose the p53 pathway thanks to deletion and methylation of the p53 effector Apaf-1 (Nature 2001, 409:207-211). The Apaf-1 locus shows over 40% loss of heteroz

By | January 15, 2001

Many cancers become resistant to chemotherapeutic drugs thanks to loss of the p53 protein, which promotes cell cycle arrest and apoptosis in response to certain drugs. Metastatic melanomas are unusual in that, despite their chemoresistance, they retain functional p53. In the January 11 Nature, Soengas et al. find that these melanomas still lose the p53 pathway thanks to deletion and methylation of the p53 effector Apaf-1 (Nature 2001, 409:207-211). The Apaf-1 locus shows over 40% loss of heterozygosity in melanomas, and in these cells the remaining Apaf-1 gene is no longer expressed. Expression and chemoresistance can be reactivated by addition of either a methylation inhibitor or a functional Apaf-1 gene.

Advertisement
Advertisement

Popular Now

  1. How Fats Influence the Microbiome
  2. Opinion: Making Progress by Slowing Down
  3. Censored Professor Quits
    The Nutshell Censored Professor Quits

    Alice Dreger is resigning from the faculty of Northwestern University, claiming that the administration censored her work in a faculty journal.

  4. Mitochondria Exchange
    News Analysis Mitochondria Exchange

    A decade of research on intercellular mitochondrial transfer has answered some long-standing questions and raised new ones.

Advertisement
Advertisement