Tales of PU

Members of the PU.1/Spi family of Ets-type transcription factors play key roles in mammalian hematopoiesis and lymphoid development. Lymphocytes are found in jawed vertebrates, including cartilaginous fish, but not in jawless vertebrates or invertebrates. In the January 16 Proceedings of the National Academy of Science Anderson et al. identified three PU.1 members in the cartilaginous fish Raja eglanteria (skate)(Proc Natl Acad Sci USA 2001, 98:553-558).

By | January 22, 2001

Members of the PU.1/Spi family of Ets-type transcription factors play key roles in mammalian hematopoiesis and lymphoid development. Lymphocytes are found in jawed vertebrates, including cartilaginous fish, but not in jawless vertebrates or invertebrates. In the January 16 Proceedings of the National Academy of Science Anderson et al. identified three PU.1 members in the cartilaginous fish Raja eglanteria (skate)(Proc Natl Acad Sci USA 2001, 98:553-558). Phylogenetic analysis established that one of the skate sequences is the ortholog of PU.1, one the ortholog of related Spi-C, and the third a divergent Spi-D gene. The skate PU.1 genes are expressed specifically in hematopoietic tissues. The strong conservation between skate and mammalian PU.1 members underscores their critical role in the development of the immune system.

Popular Now

  1. Top 10 Innovations 2016
    Features Top 10 Innovations 2016

    This year’s list of winners celebrates both large leaps and small (but important) steps in life science technology.

  2. Gut Microbes Linked to Neurodegenerative Disease
  3. Pubic Hair Grooming Linked to STI Risk
    The Nutshell Pubic Hair Grooming Linked to STI Risk

    Observational study suggests pubic hair grooming correlates with heightened risk of acquiring sexually transmitted infections, although causation remains unclear.

  4. Naive T Cells Find Homes in Lymphoid Tissue
Rockland