Ephrin-B3 protein linked to mirror-movement disorder

Researchers from the University of Texas Southwestern Medical Center found that mice lacking the protein ephrin-B3 showed signs of a rare condition known as mirror-movement disorder.The main symptom of the disease is an involuntary symmetrical movement of the limbs so, for example, when the right hand is moved the left involuntarily moves with it.Previous research has suggested that mirror movement is caused by defects in the corticospinal tract, and ephrins are known to regulate nerve growth wi

By | January 25, 2001

Researchers from the University of Texas Southwestern Medical Center found that mice lacking the protein ephrin-B3 showed signs of a rare condition known as mirror-movement disorder.

The main symptom of the disease is an involuntary symmetrical movement of the limbs so, for example, when the right hand is moved the left involuntarily moves with it.

Previous research has suggested that mirror movement is caused by defects in the corticospinal tract, and ephrins are known to regulate nerve growth within this tract. Mark Henkemeyer explains in January Neuron: "Ephrin-B3 is a very important molecule as it is expressed down the middle of the spinal column. It serves as a repulsive barrier that keeps the left axons on the left side of the nervous system and the right axons on the right." Henkemeyer's group reports that mice genetically engineered to lack the ephrin-B3 protein display a kangaroo-like hopping gait involving both their forelimbs and hind limbs, among other mirror movements.

The authors hope their findings may prove helpful in the regeneration of nerves in people with spinal cord injuries.

Advertisement

Popular Now

  1. NYU Halts Studies, Suspends Investigator
    The Nutshell NYU Halts Studies, Suspends Investigator

    Experiments conducted at the New York University School of Medicine violated several research standards, according to US Food and Drug Administration investigators.

  2. Exercise-Induced Muscle Factor Promotes Memory
  3. The Meaning of Pupil Dilation
    Daily News The Meaning of Pupil Dilation

    Scientists are using pupil measurements to study a wide range of psychological processes and to get a glimpse into the mind.

  4. Brexit’s Effects on Science
Biosearch Technologies