Structure of a biological propeller

explains how bacteria can switch between 'running' and 'tumbling' motions.

By | March 15, 2001

The flagellum, the organelle that enables bacteria to swim, consists of a long, thin filament that is rotated at hundreds of revolutions per second by a motor embedded in the cell surface. The filament is essentially a tube made up of 11 protofilaments arranged as a helical supercoil. By switching between left- and right-handed helical twists (the L and R states, respectively), a bacterium can switch between 'running' and 'tumbling' (reorientating) motions. In the 15 March Nature, a team led by Keiichi Namba of the Protonic NanoMachine Project and Matsushita Electric Industrial Company, Kyoto, Japan, provides an insight into how filaments are able to switch helical states (Nature 2001, 410:331-337).

Each protofilament contains thousands of copies of the protein flagellin, aligned one of top of another. Namba and colleagues crystallized the protein and analysed its structure at atomic (2Å) resolution. Flagellins of both the L and R states crystallized only into the R state. To simulate the slightly longer L protofilament, the authors used a computer program to gradually stretch their R-type protofilament images. At one point, an abrupt change in conformation was seen in a local feature of the structure. Samatey et al suggest that this may be the key event in switching.

This molecular switching mechanism will be of interest to nanotechnologists who are trying to develop tiny propeller-driven biomolecular devices that could move around the body repairing cells and dispensing drugs.


Popular Now

  1. Birth of the Skin Microbiome
    Daily News Birth of the Skin Microbiome

    The immune system tolerates the colonization of commensal bacteria on the skin with the aid of regulatory T cells during the first few weeks of life, a mouse study shows.

  2. Inside a Lab Mouse’s High-Fat Diet
  3. Battling the Bulge
    Bio Business Battling the Bulge

    Weight-loss drugs that target newly characterized obesity-related receptors and pathways could finally offer truly effective fat control.

  4. How Gastric Bypass Can Kill Sugar Cravings
Life Technologies