Advertisement
BD Biosciences
BD Biosciences

Can NK cells maintain the remission of MS?

Natural killer cells from multiple sclerosis patients in remission have properties resembling those of NK type 2 cells, which can favour functional deviation of T cells toward Th2 and prohibit autoimmune effector T cells.

By | March 16, 2001

Multiple sclerosis (MS) is a Th1-mediated autoimmune disease characterised by relapses followed by clinically stable remissions. A new hypothesis suggests that regulatory immune cells may play an active part not only in relapses but also in maintaining the remission of MS. In the Journal of Clinical Investigation (published online ahead of print), Takahashi et al provide the first evidence of a role for natural killer (NK) cells in the remission of MS (J Clin Invest 2001, 107:R23-R29).

Kazuya Takahashi and colleagues examined NK cells in the peripheral blood of 22 patients with MS and found that during remissions these cells were characterized by an elevation of IL-5 mRNA and a decreased expression of IL-12Rβ2 mRNA. Moreover, the NK cells produced larger amounts of IL- 5 than controls after non-specific stimulation.

These features resemble those of NK type 2 cells, which can favour functional deviation of T cells toward Th2 and prohibit autoimmune effector T cells. The NK cells lost the NK2-like property when relapse of MS occurred but regained it after recovery. Targeting NK cells with immunological interventions such as NK bias may benefit patients with MS.

Advertisement
ASM
ASM
Advertisement

Popular Now

  1. The Mycobiome
    Features The Mycobiome

    The largely overlooked resident fungal community plays a critical role in human health and disease.

  2. Antibody Alternatives
    Features Antibody Alternatives

    Nucleic acid aptamers and protein scaffolds could change the way researchers study biological processes and treat disease.

  3. Circadian Clock and Aging
    Daily News Circadian Clock and Aging

    Whether a critical circadian clock gene is deleted before or after birth impacts the observed aging-related effects in mice.

  4. Holding Their Ground
    Features Holding Their Ground

    To protect the global food supply, scientists want to understand—and enhance—plants’ natural resistance to pathogens.

Advertisement
Advertisement
Life Technologies