Advertisement

strain differences influence host responses

Patients with chronic gastritis produced by Helicobacter pylori are at risk of duodenal and gastric ulceration and gastric cancer. The majority of H. pylori-colonized individuals remain asymptomatic, however, and the mechanism of this resistance is not fully understood. A study published in the March issue of Journal of Clinical Investigation shows that genetic differences between strains of Helicobacter pylori influence host inflammatory responses (J Clin Invest 2001, 107:611-620). Dawn Israel

By | March 19, 2001

Patients with chronic gastritis produced by Helicobacter pylori are at risk of duodenal and gastric ulceration and gastric cancer. The majority of H. pylori-colonized individuals remain asymptomatic, however, and the mechanism of this resistance is not fully understood. A study published in the March issue of Journal of Clinical Investigation shows that genetic differences between strains of Helicobacter pylori influence host inflammatory responses (J Clin Invest 2001, 107:611-620).

Dawn Israel and colleagues examined in a gerbil model the ability of duodenal and gastric ulcer strains of H. pylori isolates to induce differential host responses in vivo or in vitro. Gastric ulcer strain B128 induced more severe gastritis than did duodenal ulcer strain G1.1. DNA hybridization to a whole H. pylori genome microarray identified a large deletion of the cag pathogenicity island in duodenal ulcer strain G1.1. Partial and complete disruption of the cag island in gastric strain B128 attenuated induction of IL-8 in vitro and significantly decreased gastric inflammation in vivo, suggesting that the ability of H. pylori strains to induce epithelial inflammation is dependent on the presence of an intact cag pathogenicity island.

The authors conclude that "Genotypic markers could be developed not only to identify individuals at risk for specific clinical sequelae of infection, but also to permit selective targeting of therapy for disease prevention."

Advertisement
Advertisement

Popular Now

  1. Antibiotics and the Gut Microbiome
  2. Sex Differences in Pain Pathway
  3. The Sum of Our Parts
    Features The Sum of Our Parts

    Putting the microbiome front and center in health care, in preventive strategies, and in health-risk assessments could stem the epidemic of noncommunicable diseases.

  4. Anti-Vax Doctor Found Dead
    The Nutshell Anti-Vax Doctor Found Dead

    Police are calling the death of James Bradstreet, a physician who claimed vaccines cause autism and offered autism cures to patients, an apparent suicide.

Advertisement
Bina Technologies
Bina Technologies
Advertisement
The Scientist