An emerging pattern
Three studies shed new light on how members of the bone morphogenetic protein family are regulated during embryonic development.
During development, organizing centres at key locations in the embryo secrete morphogens that become distributed in a concentration gradient. It is thought that cells along the gradient adopt different fates depending on the concentration of the morphogen they encounter. In the 22 March Nature, three studies shed light on the elaborate regulation of some potent morphogens — members of the bone morphogenetic protein (BMP) family.
All three studies focus on the role of the Twisted gastrulation (Tsg) protein and find that, in both vertebrates and invertebrates, this protein binds to members of the BMP family, preventing them from signalling. The authors — Jeffrey Ross of the University of Minnesota and co-workers, Ian Scott of the University of Wisconsin Medical School and co-workers, and Chenbei Chang of Rockefeller University and colleagues — studied Tsg function in Drosophila (Nature 2001, 410:479-483), Xenopus (Nature 2001, 410:475-478) and the zebrafish (Nature 2001, 410:483-487), respectively.
Their findings lead to the following model of BMP regulation. In Drosophila, Decapentaplegic (Dpp), a BMP, forms a complex with Tsg and with a second inhibitor, Short gastrulation (Sog). The levels of Dpp are controlled by local production of Sog. When Sog is proteolytically degraded, Dpp is released in its active form. Tsg increases the binding of Dpp to Sog but also accelerates the degradation of Sog when the protease is present. In regions of the embryo where levels of Sog are high, degradation of Sog has little effect because there is plenty more around to form a complex with Dpp and Tsg. In areas where Sog is scarce, Dpp is released. These interactions also occur in vertebrates, where Chordin — a relative of Sog — binds to Tsg and BMP4, a relative of Dpp.