Trefoil peptides are small proteins secreted by the gastric antral and pyloric glands and are found in high concentrations around sites of gastric ulceration. TFF2 stimulates cell motility and is probably the principal cytoprotective trefoil peptide in the stomach. In May
Using quantitative western transfer analysis Semple
The increase in TTF2 is probably designed to facilitate repair of gastric mucosa at night. These results could suggest that missing out on a good night's sleep through partying, long haul travel or shift work may increase the risk of gastric ulcers.