Transplanted pancreatic cells, including β cells, have been shown to re-establish the production of insulin in the pancreas but unfortunately, the demand for β cells far outweighs the supply. In October
The 3-phosphoinositide–dependent protein kinase Akt is a signaling molecule that mediates the actions of insulin and insulin-like growth factor 1. Tuttle
"The ability of activated Akt1 to antagonize the β cell loss of experimental diabetes has obvious therapeutic implications" suggested the authors. "Since the death rate and the division rate did not change in our mice, it is possible that Akt1 also promotes the growth of new β cells" said Morris Birnbaum the senior author on the paper.