Manipulation of mosquitoe genes to make resilient to malaria infection is very interesting but requires some thinking about its utility under field conditions. Moreover, we have read many such manipulations under the broad heading of "biological control". I wonder how many of such novel and laboratory conceived ideas have been successfully applied to field conditions? How far this research is going to be practically useful? Billions of dollars have been spent to control mosquitoes and good old "DDT" is back into action. Yet mosquitoes are resilient for control and they are still propagated without any impedence. No doubt vectors play very important role in dissemination of infection. This work, in my opinion should change its direction. They should consider the possibility of making the mosquitoes sterile by gene manipulation. If such approach can be achieved, then one can envisage the mosquitoe population undergoing sterility and thereby a direct hit on vector dissemination. This may have a broader applications and can be applied to many other vector-borne infections. Best of luck in their research.