Coincidentally, the journal Science (27 Jul, 317:477; Dosante et al.) published a report that raises some issues for AAV vectors. A consistent integration at a locus (on mouse Chrom. 7)associated with microRNA, in hepatocarcinomas that developed at an increased incidence (56% AND 33% incidence with two different AAV constructs, vs 8% in controls). \n\nIt certainly suggests to me that AAV vector safety needs some more scrutiny. At least to rule out that similar integrations occur on chomosome 14 in human hepatocytes.