DNA damage resets body clock

DNA damage resets the circadian clock in mammals, researchers report in this week's online issue of linkurl:__Current Biology.__;http://www.current-biology.com/content/future Previous studies have shown that DNA damage affects circadian cycles in the fungus __Neospora__. Here, Malgorzata Oklejewicz at Erasmus University Medical Center in the Netherlands and colleagues demonstrated the effect not only in mammalian cell lines, but also in mice in vivo. "This interaction between DNA damage respon

By | February 21, 2008

DNA damage resets the circadian clock in mammals, researchers report in this week's online issue of linkurl:__Current Biology.__;http://www.current-biology.com/content/future Previous studies have shown that DNA damage affects circadian cycles in the fungus __Neospora__. Here, Malgorzata Oklejewicz at Erasmus University Medical Center in the Netherlands and colleagues demonstrated the effect not only in mammalian cell lines, but also in mice in vivo. "This interaction between DNA damage response and the circadian clock is preserved through evolution," said Roman Kondratov, a cancer biologist at the Cleveland State University, who was not involved in the study. The researchers treated mammalian cells with a number of DNA-damaging agents: ionizing radiation, ultraviolet light and a chemical compound that causes oxidation, and looked at the subsequent expression of __mPER2__, a key linkurl:circadian clock gene.;http://www.the-scientist.com/news/home/53160/ They saw that the amount that the clock shifted forward, as indicated by a shift in gene expression, depended on the dose of radiation. They also found that ATM kinase, which is known to initiate DNA repair, was responsible for communicating DNA damage to the clock machinery. The clock shift also had behavioral effects: Mice treated with non-lethal irradiation moved their activity cycles forward. Earlier research has shown that circadian cycles can affect a cell's response to DNA damage, which has implications for the time of day patients are treated with chemotherapy or radiation, said Kondratov. The new study suggests that the relationship between DNA damage and the circadian clock may go both ways, and could provide an explanation for side-effects of cancer therapies. As to whether the findings will affect cancer treatment, Kondratov said, it's too early to tell. "We still don't know how big the effect will be in humans."

Popular Now

  1. Monsanto Buys Rights to CRISPR
    The Nutshell Monsanto Buys Rights to CRISPR

    The US agribusiness secures a global, nonexclusive licensing agreement from the Broad Institute to use the gene-editing technology for agricultural applications.

  2. How Plants Evolved Different Ways to Make Caffeine
  3. ESP on Trial
    Foundations ESP on Trial

    In the 1930s, parapsychologist Joseph Banks Rhine aimed to use scientific methods to confirm the existence of extrasensory perception, but faced criticisms of dubious analyses and irreproducible results.

  4. Another DNA Vaccine for Zika Shows Promise
RayBiotech