Milestone for RNAi therapeutics?
A company developing therapeutics using RNA interference (RNAi) today (February 29) linkurl:announced;http://phoenix.corporate-ir.net/phoenix.zhtml?c=148005&p=irol-newsArticle&ID=1113937&highlight= positive results of a clinical trial in humans ?
A company developing therapeutics using RNA interference (RNAi) today (February 29) linkurl:announced;http://phoenix.corporate-ir.net/phoenix.zhtml?c=148005&p=irol-newsArticle&ID=1113937&highlight= positive results of a clinical trial in humans ? marking a first for the much-touted promise of RNAi-based therapies.
Alnylam, based in Cambridge, Mass., exposed 88 male volunteers to respiratory syncytial virus, which affects mostly young children and the elderly. Half of the subjects received the RNAi treatment, delivered as a nasal spray, which blocked a protein made by the virus, while the other half received a placebo. The upshot: 67% of the treatment group became infected with the virus, while 88% of the placebo group were infected, the linkurl:Wall Street Journal;http://online.wsj.com/article/SB120425827872802381.html?mod=health_home_stories reports; though small, the difference was statistically significant.
Researchers have placed high hopes on the potential for RNAi-based therapies, but have linkurl:struggled;http://www.the-scientist.com/blog/display/54268/ with delivery strategies. "With the positive results from GEMINI, we believe that Alnylam has demonstrated the first ever human proof of concept with an RNAi therapeutic," said John Maraganore, the compan"?s CEO, in a press release. The results are not published, but further details of the study will be described this weekend at the International Symposium on Respiratory Viral Infections in Singapore.
April 8, 2009
Hi guys, as we know drug is a silent killer. Before it kills us, we must kill it. I meant we must destruct it. So, strictly say no for the drugs. Futures more, please encourage your family members or friends to go on with intervention if they drug addicted.\n___________________________________________________\nMark Fletcher \n\nDrug Intervention New Mexico