In 1984, the whole premise supporting the claim of a new retrovirus as the probable cause of AIDS, was the promise of a vaccine within 2 years.\n\n24 years later, still no vaccine. Billions of dollars spent, still no vaccine.\n\nIn December of 2007, Anthony Fauci stated in the New England Journal of Medicine, "To be brutally honest with ourselves, we have to leave open the possibility . . . that we might not ever get a vaccine for HIV."\n\nRecently, on March 26, 2008, Fauci is quoted in a New York Times article entitled "Rethinking is Urged on a Vaccine for AIDS," as stating: "There is not an immediate solution to the problem." He also stated," [e]verything is on the table."\n \nPerhaps the problem is that AIDS researchers are barking up the wrong scientific tree. The efforts at "rethinking" is really just offering more of the same. It is paradoxical that the clinical disease is diagnosed by the detection of anti-bodies, which for some diseases would indicate a successful clearance of the offending microbe, not a future disintegration of one's immune system, opportunistic infection and death.\n\nTo truly "rethink" the issue, one must go back to first principles. Part of the definition of AIDS is "Immune Deficiency"\n\nOne could re-classify Diabetes as "Insulin Deficiency" where the course of treatment is self-evident -- give patients insulin.\n\nSame thing with AIDS. Perhaps, instead of toiling away at mimicking the virus to generate an immune response, these AIDS researchers should be trying to reconstitute the immune system of the person infected. Simply put, address the "immune deficiency," not the virus.\n\nCertainly, such effort could not be more cumbersome, expensive, wasteful and unproductive as the unending efforts to develop a vaccine.\n\nWe all share the same objective: to cure AIDS. Perhaps, as Fauci suggested some greater "rethinking" is in order.