"In humans, Dillin said, this enzyme pathway is conserved, so it may be possible to find compounds that alter the activity of these enzymes, essentially tricking the human body into thinking it is calorie-restricted under normal dietary conditions."\nIt is most likely possible. Why not? However, what will be the consequences? These genes are likely functioning as switches between catabolic and anabolic processes. (For example, one of the functions of FOXA is a regulation of glucose metabolism.) If we would "trick" our bodies to eat (catabolize) themselves under conditions of plentiful food supply, the least thing we might gain is a crazy high level of sugar in the blood. Just another way to get diabetes, not longevity. I would be glad to be mistaken about that, though.