The article states:\n"By blocking the release of calcium from the endoplasmic reticulum -- an intracellular source of calcium -- the researchers mimicked the effects of the presynaptic presenilin knockouts in control mice. This result points to intracellular calcium release as a possible mechanism by which presenilins regulate neuronal function. / 'The main take home message is there is a difference in the way neurons process calcium levels in absence of presenilins, and that has an effect on synaptic [function]," said Bezprozvanny.'"\n\nDuh? If the report re blockage of calcium release mimicking presenilin knockout is accurate, and if Bezprozvanny's quote is also accurate, then Bezprozvanny's quote is not necessarily logical. In the absence of any evidence to the contrary, it could equally well be that intracellular calcium elevation is required to activate or potentiate the presenilin function, either directly or indirectly (through either an upstream or downstream mechanism).