Top 7 papers in neuroscience

A snapshot of the highest-ranked articles in neuroscience and related fields, as ranked by F1000

By | November 9, 2010

linkurl:1. Mechanotransduction proteins found; A family of proteins, called Piezos, has been identified as important players in mechanically activated ion channels, which make possible several senses, such as hearing, touch and pain sensation. B. Coste, et al., linkurl:Science,; 330:55-60, 2010. Evaluations by M. Moran and D. Kimball, Hydra Biosciences; J. Garcia-Anoveros, Northwestern University; F. Viana, UMH Instituto de Neurociencias; P. Garrity, Brandeis Univ; B. Nilius, KU Leuven. linkurl:Free F1000 Evaluation; linkurl:2. Epigenetics in mind;
Mouse litter
linkurl:Seweryn Olkowicz;
The body's tendency to silence the expression of one parental allele in favor of the other -- a practice known as genomic imprinting -- is much more widespread in the brain than scientists have believed, according to a new genome-wide study in mice. Surprisingly, more than 1300 genes in the mouse brain appear to exhibit "parent-of-origin" epigenetic effects. C. Gregg, et al., linkurl:Science,; 329:643-8, 2010. Evaluations by R. Sapolsky, Stanford University; M.E. Carter and L. de Lecea, Stanford Univ; J. Messing, Rutgers University; Y. Ikeuchi and A. Bonni, Harvard Medical School; D. Sweatt, University of Alabama at Birmingham. linkurl:Free F1000 Evaluation; linkurl:3. Translation goes local; Protein synthesis is a complicated game, but for the first time researchers have shown direct interaction between a transmembrane receptor, called DCC, with translational machinery in neurons, a step that likely facilitates localized protein manufacture. J. Tcherkezian, et al., linkurl:Cell,; 141:632-44, 2010. Evaluations by R. Darnell, Rockefeller Univ; K. Kwan and C.B. Chien, Univ Utah; J. Heraud and M. Kiebler, Ctr for Brain Res, Med Univ Vienna, Austria; W. Kroeze and B. Roth, Univ North Carolina; L. Desgroseillers, Univ Montreal, Canada; L. Columbus, Univ Virginia. linkurl:Free F1000 Evaluation; linkurl:4. What makes neurons dependent; Neurons in the peripheral nervous system need specific secretory molecules to survive during development while neurons in the central nervous system do not, and researchers now know why. Neurons in the PNS express two neurotrophin receptors, TrkA and TrkC, that induce cell death in absence of their ligands, while neurons in the CNS express receptor TrkB, which does not. V. Nikoletopoulou, et al., linkurl:Nature,; 467:59-63, 2010. Evaluations by A.M. Davies, Cardiff University; M. Bothwell, University of Washington; H. Nakamura, Tohoku University, Japan. linkurl:Free F1000 Evaluation; linkurl:5. How the cortex interprets context; New findings illustrate the physiological underpinnings of animals' ability to change their response to external stimulus depending on the context of the situation. The firing activity of neurons in the brain is context-dependent -- when monkeys are confronted with identical visual stimuli, their neuronal activity varies depending on which of two different perceptual tasks they perform. M.R. Cohen, et al., linkurl:Neuron,; 60:162-73, 2008. Evaluations by M. Carandini, University College London; B. Cumming, NEI; D. Angelaki, Washington University School of Medicine. linkurl:Free F1000 Evaluation; linkurl:6. Fusion in a snap; Fewer SNARE complexes -- bundles of SNAP receptors that mediate vesicle fusion -- are required for vesicle-membrane fusion during exocytosis than previously believed. Past estimates ranged up to eleven SNARES, but fast fusion requires as few as three and slow fusion may need as few as one, according to new evidence. R. Mohrmann, et al., linkurl:Science,; 330:502-5, 2010. Evaluations by L. Tamm, University of Virginia; Y. Xu and D. Tommre, Yale University School of Medicine; D. Stevens and J. Rettig, Universitaet des Saarlandes. linkurl:Free F1000 Evaluation; linkurl:7. The value of diversity; Neuronal diversity -- variability in the electrophysiological properties of neurons -- is not just chance imprecision but a valuable feature of the nervous system. Diverse populations of neurons in the mouse olfactory bulb code more information than their homogeneous counterparts, researchers find. K. Padmanabhan, et al., linkurl:Nat Neurosci,; 13:1276-82, 2010. Evaluations by B. Brembs, Freie Universitat Berlin; R. Wilson, Harvard Medical School. linkurl:Free F1000 Evaluation; The F1000 Top 7 is a snapshot of the highest ranked articles from a 30-day period on Faculty of 1000 Neuroscience, as calculated on November 8, 2010. Faculty Members evaluate and rate the most important papers in their field. To see the latest rankings, search the database, and read daily evaluations, visit linkurl:;
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[2nd November 2010]*linkurl:Top 7 hidden jewels;
[26th October 2010]




Posts: 26

November 9, 2010

The article mistakenly states the following:\n\n"5. How the cortex interprets context \n...\nM.R. Cohen, et al., Neuron, 60:162-73, 2010."\n\nThe correct citation:\nMarlene R. Cohen and William T. Newsome 2008 "Context-Dependent Changes in Functional Circuitry in Visual Area MT" _Neuron_ 60(1) pp. 162 - 173.
Avatar of: Megan Scudellari

Megan Scudellari

Posts: 9

November 10, 2010

Thank you for your sharp eyes Dennis. The correction has been made.\n\n-Megan Scudellari\nThe Scientist

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