linkurl:1. New clue to self-tolerance;http://f1000.com/5685958?key=sswwkkrpjfr7hxf Researchers identify a new population of regulatory T cells, important players in immunological self-tolerance, which can be induced by cytokine interleukin IL-35. These iTr35 cells, which can themselves make IL-35 and initiate the production of more iTr35 cells, can suppress and regulate immune responses in a variety of pathogenic models in mice, opening up a new direction in immunology research and presenting possible therapeutic implications.L. W. Collison, et al., "IL-35-mediated induction of a potent regulatory T cell population," linkurl:Nat Immunol,;http://www.ncbi.nlm.nih.gov/sites/entrez/20953201?dopt=Abstract&holding=f1000%2Cf1000m 2010. Evaluated by Stephen Cobbold, University of Oxford; Stanley Perlman, University of Iowa. linkurl:Free F1000 Evaluation;http://f1000.com/5685958?key=sswwkkrpjfr7hxf
Neutrophil immune cell engulfing anthrax bacteria
Image: Wikimedia commons, Etxrge
linkurl:2. Another route to helper T;http://f1000.com/5750956?key=fd6jvlszdhbxkcj T helper 17 cells, which are crucial for host defense and autoimmunity, can differentiate in the absence of TGF-β signaling, contrary to conventional wisdom on Th17 differentiation. Th17 cells derived without...
K. Ghoreschi, et al., "Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling," linkurl:Nature,;http://www.ncbi.nlm.nih.gov/sites/entrez/20962846?dopt=Abstract&holding=f1000%2Cf1000m 467:967-71, 2010. Evaluated by: Wuzhou Wan and Philip Murphy, National Institute of Allergy and Infectious Diseases; Jeremy McAleer and Jay Kolls, Lousianna State University Health Sciences Centre; Robert Booth, Virobay Inc. linkurl:Free F1000 Evaluation;http://f1000.com/5750956?key=fd6jvlszdhbxkcj linkurl:3. Natural killer cells adapt, too;http://f1000.com/5808956?key=5qhq80hx23pyxfp S. Paust, et al., "Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses," linkurl:Nat Immunol,;http://www.ncbi.nlm.nih.gov/sites/entrez/20972432?dopt=Abstract&holding=f1000%2Cf1000m 2010. Evaluated by: Sumi Rajagopalan and Eric Long, National Institute of Allergy and Infectious Diseases; Eric Vivier, Centre d'Immunologie de Marseille-Luminy. linkurl:Free F1000 Evaluation;http://f1000.com/5808956?key=5qhq80hx23pyxfp linkurl:4. Key differentiation factor elucidated;http://f1000.com/4942963?key=rqw76cqskm8xcqr R. Gandhi, et al., "Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells," linkurl:Nat Immunol,;http://www.ncbi.nlm.nih.gov/sites/entrez/20676092?dopt=Abstract&holding=f1000%2Cf1000m 11(9):846-53, 2010. Evaluated by: Byron Vaughn, Moritz Schmelzle and Simon Robson, Beth Israel Deaconess Medical Center; Ru Zhou and Rachel Caspi, National Eye Institute, NIH. linkurl:Free F1000 Evaluation;http://f1000.com/4942963?key=rqw76cqskm8xcqr linkurl:5. Avoiding self destruction;http://f1000.com/5389963?key=1lxmypmj55y3xm9 H.J. Kim, et al., "Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance," linkurl:Nature,;http://www.ncbi.nlm.nih.gov/sites/entrez/20844537?dopt=Abstract&holding=f1000%2Cf1000m 467(7313):328-32, 2010. Evaluated by: Takeshi Tsubata, Tokyo Medical and Dental University; Bryce A Binstadt, University of Minnesota. linkurl:Free F1000 Evaluation;http://f1000.com/5389963?key=1lxmypmj55y3xm9 linkurl:6. miRNA regulation in immunity;http://f1000.com/5762957?key=0zcs1d8kl8p4y78 L.F. Lu, et al., "Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses," linkurl:Cell,;http://www.ncbi.nlm.nih.gov/sites/entrez/20850013?dopt=Abstract&holding=f1000%2Cf1000m 142(6):914-29, 2010. Evaluated by: Astar Winoto, University of California, Berkeley. linkurl:Free F1000 Evaluation;http://f1000.com/5762957?key=0zcs1d8kl8p4y78 linkurl:7. Complement-mediated asthma;http://f1000.com/5622958?key=1ywg798380515b2 S. Lajoie, et al., "Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma," linkurl:Nat Immunol,;http://www.ncbi.nlm.nih.gov/sites/entrez/20802484?dopt=Abstract&holding=f1000%2Cf1000m 11(10):928-35, 2010. Evaluated by: Thirumalai Ramalingam and Thomas Wynn, National Institutes of Health; Sarah Gaffen, University of Pittsburgh. linkurl:Free F1000 Evaluation;http://f1000.com/5622958?key=1ywg798380515b2



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