Top 7 in neuroscience

A snapshot of the highest-F1000-ranked articles in neuroscience and related areas

By | January 24, 2011

linkurl:1. Clock calibrated by temp;
Mouse cingulated cortex neurons
Image: Wikimedia commons, Shushruth
The suprachiasmatic nucleus, a tiny area in the middle of the brain responsible for controlling circadian rhythms, uses small fluctuations in the body temperatures of mammals to coordinate the daily rhythms of tissues throughout the body. E.D. Buhr ED, et al., "Temperature as a universal resetting cue for mammalian circadian oscillators," linkurl:Science,; 330:79-85, 2010. Evaluated by Jean Clairambault, INRIA; Patrick Fuller and Clifford Saper, Beth Israel Deaconess Med Cen, Harvard Med School; Ralph Mistlberger, Simon Fraser Univ; Stacey Harmer, UC Davis. linkurl:Free F1000 Evaluation; linkurl:2. Prozac transforms neurons; In Prozac-treated mice, increased levels of the microRNA miR-16 reduces the expression of the serotonin transporter (SERT) in serotonergic neurons, while decreased miR-16 levels in noradrenergic neurons turns on the expression of serotonergic functions, suggesting that antidepressants can modify the neuronal phenotype. A. Baudry, et al. "miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants, " linkurl:Science,; 329:1537-41, 2010. Evaluated by Mark Millan, Centre de Recherches de Croissy; Zachary Weil and Randy Nelson, Ohio State Univ College of Med; Irwin Lucki, Univ of Pennsylvania; Bryan Roth, Univ of North Carolina. linkurl:Free F1000 Evaluation; linkurl:3. Flies have "eyes" on their backs; Drosophila larvae can sense ultraviolet, violet and blue light via a special class of neurons that line their body wall. This novel and unexpected photosensory system appears to mediate light avoidance in the well-studied model organism, enabling larvae to detect light over their entire bodies and move away from danger. Y. Xiang, et al., "Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall," linkurl:Nature,; 468:921-6, 2010. Evaluated by Steven Reppert, Univ of Mass Med School; Gray Lyons and Chay T Kuo, Duke Univ Med Cen. linkurl:Free F1000 Evaluation; linkurl:4. Dopamine does and doesn't help learning; In contrast to the dominant hypothesis about Pavlovian conditioning -- such as associating a cue with a food reward -- dopamine signaling is not required for learning in rats that approach a food reward when a cue is presented. It is, however, a key component of learning in rats that approach the cue itself, possibly providing insight into the neurobiology of impulse control disorders. S.B. Flagel, et al., "A selective role for dopamine in stimulus-reward learning," linkurl:Nature,; 469:53-7, 2010. Evaluated by Björn Brembs Freie Univ Berlin; Xiaoxi Zhuang, Univ of Chicago. linkurl:Free F1000 Evaluation; linkurl:5. Shuffling neurons aids spatial memory; Certain regions in the rat hippocampus are reorganized upon learning novel locations of food rewards, and reactivating those new arrangements is critical to the long-term memory of the food locations. D. Dupret, et al., "The reorganization and reactivation of hippocampal maps predict spatial memory performance," linkurl:Nat Neurosci,; 13:995-1002, 2010. Evaluated by Lisa Giocomo and Edvard I Moser, Norwegian Univ of Sci and Tech; Howard Eichenbaum, Boston Univ. linkurl:Free F1000 Evaluation; linkurl:6. Fear fighting neurons; Researchers reveal the molecular-level anatomical details of the amygdala's control over fear responses, identifying an inhibitory subset of neurons responsible for controlling fear, which may provide clues for the treatment of fear-related disorders. W. Haubensak, et al., "Genetic dissection of an amygdala microcircuit that gates conditioned fear," linkurl:Nature,; 468:270-6, 2010. Evaluated by Kerry Ressler, Yerkes National Primate Res Cen; Matt E Carter and Luis de Lecea, Stanford Univ. linkurl:Free F1000 Evaluation; linkurl:7. Lungs can taste; The cilia lining the human airway, responsible for ejecting harmful inhaled material, express bitter taste receptors, beating more in response to noxious substances, possibly as a defensive mechanism to prevent harmful compounds from reaching the lungs. A.S. Shah, et al., "Motile cilia of human airway epithelia are chemosensory," linkurl:Science,; 325:1131-4, 2009. Evaluated by Stephen Roper, Univ of Miami School of Med; Arturo Alvarez-Buylla, Univ of Calif; Sue Kinnamon, Colorado State Univ. linkurl:Free F1000 Evaluation; The F1000 Top 7 is a snapshot of the highest ranked articles from a 30-day period on Faculty of 1000 Neuroscience, as calculated on January 20, 2011. Faculty Members evaluate and rate the most important papers in their field. To see the latest rankings, search the database, and read daily evaluations, visit linkurl:;
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January 28, 2011

Piezo electric squeezing and reflective images on solar-lunar interfering domains out of standing waves In Far Infra regions of semiblackholes Rahu and Kethu \nThe Cape Renewable Energy research center is interested in some communication domains of space antenna that can be designed in future based on their Astrogenetic observations. Their further research in Astrogenetics seems to be a surprising contribution in future genome technology.\nRahu and Kethu affecting the brain growth and Neuron behaviour:Far infra rays are biogenetic waves ranging from 6 microns to 12 microns that play the role of growing living things. The lunar rays interacted with solar rays exposed to molecular action at 8-10 is called a complex water oscillations. This resonance ionization causes of water into hydrogen ions and hydroxide ions. Hence the neuron behaviour and growth of the brain is decided by the standing wave interaction between Rahu and lunar rays which absorption and delayed activation affects the brains memory cells. The infrared waves of the sun at 3 to 10.5 microns by the lunar standing wave nodes of Rahu and Kethu forming a red reflections and blue reflections requiring a new investigation on neuron behaviour by the Biomedical nobel laureates.\nThe information of bending of light waves by the interfering under certain conditions was their point of curiosity when some naturally occurring .The expansion and contraction of the interfering spiraled polarity reversals that bend the waves due to stoke and antistoke z dynamics drives a helical force that travel at a distance and freeze at a distance. \nDelaying time action: The opposing and attractive solenoids of spiraled of opposite poles in forming a synchronous rotational z axis separations as an oscillator produces timing pulses and as they add pole shifting counter codes as they swing act as time delaying as there will be no output for clockwise motion and pulse output for each revolution of BR - Hall?s output along the circumference of magnetic ring thus formed.\nThe interfering pattern that form the spiral bending moments of acoustic clockwise and anti clockwise directions of stoke and antistoke configuration requires an investigation in the formation of Rahu and Kethu.\nA New Kind of Search for Measuring the Existence of Rahu and Kethu\nWhen famous scientist, astrophysicist Stephen Hawkings was not convinced about the existence of two semi blackholes of the solar system responsible for astro genetic interference it was a worrying problem for Sankara Velayudhan Nandakumar ,the oxford-Cambridge-Hubble-Anna team .Yet the team has the habit of solving the problems tirelessly and even one as difficult as this is at length solved though baffled again and again. Keen minds maintained endeavour to fulfill its prophecy, until one day this will be recognized\nRahu and Kethu Astrogenetic constraints of semi blackhole absorb solar and lunar waves for secondary delayed emission act along circular to ellipsoidal frequency squeezed oscillation to deal with polarity ejection in space for design and development of laser \nstimulated antenna is space research history.\n This 1995 time-lapse movie taken by the [Hubble Space Telescope] shows sprites dancing (and being blown away) above the polar regions of the Crab pulsar. Each frame represents an interval of several weeks. The sprites are at a distance of about two light-months from the pulsar, and are probably shock fronts caused by an invisible relativistic beam of charged particles. The pulsar itself is the star at bottom center. It looks like an ordinary star in a time exposure, but the optical emission is actually in the\nForm of 30Hz flashes.\nThe practical application of this research work is in communication engineering domains of space that may cover vast distance and may form space antennas to receive and to \nCommunicative optonics.\n\nThe shadow polarized ejections are thought to be simultaneously near the Dirac critical magnetic field and the Schwarzschild gravitational limit. Under these conditions there is not good cause for supposing the still-unknown relationships between the electrical and gravitational fields can be neglected. Until the gravitational and electrical fields are unified it is doubtful that a satisfactory theoretical basis exists shifted infra asymptotic free semifor explaining the Rahu and Kethu Blackholes of shadow planets of our solar system. \nThe most commonly accepted explanation for the energy deficit is that the interference ellipsoidal mirror reflection is powered by the decay of an unusually intense magnetic field rather than by rotational kinetic energy for interfering in genes initiate Astro Genetic constraints:\nThe standing waves of sun and the moon interfered on intersecting angle evolving two opposite spindomains and ejection modes at retrograde moving domains are called Rahu and Kethu. The wave is due to gravitational field of a distant mass such as Sun and the moon. The mass is in motion, so its field must be retarded.\nIn order to do that, first transform to a frame of reference that is co-moving with the source at the retarded time. In that frame of reference, and in the weak field limit, the gravitational 4-potential along the future light cone is equivalent to the simple inverse square law relationship of the Newton theory if the particle is moving at a constant velocity. It might be otherwise if the particle is accelerated. In the case of charge, there are no experimental results showing that the acceleration makes a difference, and it will be assumed that the gravitational field behaves similarly. In other words, even though the acceleration makes a vast difference in the final global solution, the retardation equations for charge do not contain any acceleration terms. The potentials are the integral of the fields, causing them to be of lower order. The acceleration terms do not appear until the\nPotential solution is differentiated.\n \nRahu and Kethu as shadow models with increase and decrease of frequencies:\nThe One reason that oscillatory shadow models have not received much attention is that the resonant frequency must decrease as the radius decreases if gravitational contraction is to supply the energy. But a repeated radius increase and decrease the resonant frequency and increase the resonant frequency correspondingly. The oscillator developed here is probably the only one in existence with that characteristic\nHowever, because it is extraordinarily difficult to observationally distinguish between rotating and oscillating point-like radiators out of ellipsoidal to circular oscillation as distance ejectors, conforming standing waves ejecting polarized domains at a distance out\nof a feedback system along the plane of hologram.\n The electrical and gravitational fields appear to be coupled in dynamic solutions. One consequence of the coupling is that a dense magnetized sphere has a specific resonant frequency that decreases to about 0.4 Hz as the radius shrinks to the Schwarzschild radius some times from ellipsoidal structure ejects domains at a distance confirming unity to polarity theory. The magnetic force between the poles of a magnetized sphere is attractive. The force at the equator is repulsive, so the magnetic field causes an equatorial bulge. Centrifugal force also causes an equatorial bulge, thus separated at distance. The energetically preferred orientation of the magnetic field is therefore parallel to the spin axis Planck?s constant is one of the quantities in the equation for the resonant frequency\n. The limiting frequency is independent of the mass of the object and all other parameters. It is a constant of physics. In being nonlinearly coupled to the gravitational potential energy of the source, gravitational contraction can supply energy to the resonant\ncausing it to break into oscillations.\nThe standing waves of sun and the moon interfered :\nThe standing waves of sun and the moon interfered on intersecting angle evolving two opposite spindomains and ejection modes at retrograde moving domains are called Rahu and Kethu.The One reason that oscillatory shadow models have not received much attention is that the resonant frequency must decrease as the radius decreases if gravitational contraction is to supply the energy. But a repeated radius increase and decrease the resonant frequency and increase the resonant frequency correspondingly. The oscillator developed here is probably the only one in existence with that characteristic.\nQuantum chromo dynamic split-up of dark and reddish regions of spirality:\nThe basic idea of this paper is to prove that there are gluons spin 1 particles from dark blue shifted (Rahu) and red shifted (Kethu) out of neutral sheet between Sun and the Moon to deal with Quasi natured zero charge from which as R value increases to a distance. They obey Quantum chromo dynamics or QCD for short and as a consequence of the renormalization by effective coupling constant by naïve scaling depends on the energy at which it is measured and decreases to zero at very shifted Blackholes of Solarhigh energies as Asymptotic freedom. The system is that moves counter clockwise in direction counter to that of infra domain movement which absorbs solar and lunar rays and emit secondary emission after a time delay e-aT a very important phenomenon for which no investigation has been carried though they take very important part in Astro genetics. \nRahu and Kethu as Like and unlike pole opposing and attractive timers:\nThey are ring type magnets positioned at 180 degree phase difference as pi shifted domains whose direction is reversed ,the time takes the south pole to\n pass through north pole in opposing directions T1 is

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