The essence of stem cells

Researchers discover a protein that may allow already-differentiated somatic cells to become stem cells.

By | June 3, 2011

Messenchymal stem cellsNATIONAL LIBRARY OF MEDICINE

A membrane protein that acts as the glue between cells is also necessary for the ability of embryonic stem cells to differentiate into multiple tissue types, as well as for already-differentiated cells to become pluripotent. In the absence of the cell-adhesion protein E-cadherin, stem cells lose their pluripotency, researchers in Berlin found. Likewise, when differentiated cells that normally don't express E-cadherin are reprogrammed into induced pluripotent stem cells (iPSCs), they begin to produce the protein. The discovery could eventually help researchers move toward "using human somatic cells to develop stem cell therapy for diseases such as heart attack, Alzheimer's or Parkinson's disease or diabetes," said lead researcher Daniel Besser of the Max-Delbruck-Center for Molecular Medicine in a press release.

Add a Comment

Avatar of: You

You

Processing...
Processing...

Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo

Popular Now

  1. Decoding the Tripping Brain
  2. Tattoo Ink Nanoparticles Persist in Lymph Nodes
    The Nutshell Tattoo Ink Nanoparticles Persist in Lymph Nodes

    Analysis of the bodies of deceased individuals can’t determine what effect these tattoo remnants have on lymph function, but researchers suggest dirty needles aren’t the only risk of the age-old practice.

  3. Do Microbes Trigger Alzheimer’s Disease?
  4. Metabolomics Data Under Scrutiny
    Daily News Metabolomics Data Under Scrutiny

    Out of 25,000 features originally detected by metabolic profiling of E. coli, fewer than 1,000 represent unique metabolites, a study finds.

AAAS