Mitochondria at Work

Mitochondria combine hydrogen derived from dietary carbohydrates and fats with oxygen to generate heat and ATP. 

By | June 3, 2011

Infographic: Mitochondria at Work
View full size JPG | PDF
ANDREW SWIFT

Mitochondria combine hydrogen derived from dietary carbohydrates and fats with oxygen to generate heat and ATP. Electrons flowing through the electron transport chain, made up of OXPHOS complexes I through V, are used to pump protons out of the mitochondrial inner membrane. This creates an electrical charge used to generate ATP, which powers most of the cell’s biochemical reactions. As a toxic by-product of OXPHOS, mitochondria generate reactive oxygen species (ROS), called free radicals. At high levels, free radicals damage mtDNA, nuclear DNA, proteins, lipids, and other molecules in the cell. As the percentage of mutated mtDNA in a cell increases, mitochondrial energy output declines, ROS production increases, and the likelihood of cell death increases.  Through the work of Wallace and others, energy deficiency caused by these factors, as well as inherited mtDNA mutations, have been linked to numerous diseases.

Read the Full Story

Add a Comment

Avatar of: You

You

Processing...
Processing...

Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo

Popular Now

  1. Publishers’ Legal Action Advances Against Sci-Hub
  2. Metabolomics Data Under Scrutiny
    Daily News Metabolomics Data Under Scrutiny

    Out of 25,000 features originally detected by metabolic profiling of E. coli, fewer than 1,000 represent unique metabolites, a study finds.

  3. How Microbes May Influence Our Behavior
  4. Do Microbes Trigger Alzheimer’s Disease?
AAAS