Stem Cells from Banked Blood

New research demonstrates the feasibility of generating iPS cells from blood samples and using them to produce multiple tissue types.

By | June 28, 2011


Blood samples banked during the course of clinical trials and other research could serve as a valuable source of stem cells, according to a study published yesterday (June 27) in Blood. Researchers at Cellular Dynamics International (CDI), a Wisconsin-based biotech founded by stem cell biologist James Thomson, demonstrate a methodology for the creation of induced pluripotent stem cells (iPSCs) from small samples of stored blood. They also show that those iPSCs can differentiate into tissues of all three germ layers in the body, including heart, neural, and liver cells.

Importantly, the differentiated cells do not carry a genetic modification that is induced when the blood is initially stored. Researchers often use an Epstein-Barr virus (EBV) to introduce a genetic modification that keeps blood viable through freezing and thawing. But after inducing the blood cells to revert to pluripotent state, the genetic modification was lost.

The advance could allow researchers to obtain blood samples from patients with a wide variety of diseases, and create stem cell models for those disorders, CDI Chief Technology Officer Nick Seay said in a press release. “Our ability to take samples of banked blood and create EBV-free iPSCs, and use that material to manufacture cells in the quantity, quality and purity required for research, is an important step forward in the study of human biology and understanding the promise of regenerative medicine.”


Add a Comment

Avatar of: You



Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo

Popular Now

  1. Inside a Lab Mouse’s High-Fat Diet
  2. Battling the Bulge
    Bio Business Battling the Bulge

    Weight-loss drugs that target newly characterized obesity-related receptors and pathways could finally offer truly effective fat control.

  3. How Gastric Bypass Can Kill Sugar Cravings
  4. Birth of the Skin Microbiome
    Daily News Birth of the Skin Microbiome

    The immune system tolerates the colonization of commensal bacteria on the skin with the aid of regulatory T cells during the first few weeks of life, a mouse study shows.

Life Technologies