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Schizophrenia Genetics Revealed

Researchers identify new mutations in schizophrenia patients without a family history of the disease.

By | August 8, 2011

FLICKR, MARCO CASTELLANI

At least half of schizophrenia patients who have no family history of the disorder harbor de novo mutations, according to research published online on Sunday (August 7) in Nature Genetics, suggesting genetics may play a role even when the disease is not inherited.  Specifically, researchers sequenced the exomes, or protein-coding DNA, of 53 patients with seemingly non-inherited cases of schizophrenia—meaning they had no immediate family members nor aunts, uncles, nieces, nephews or grandparents who had the disease—as well as 22 unaffected individuals and the parents of these subjects. In 27 of the schizophrenia patients, they identified 40 new mutations in 40 different genes, including one in DGCR2, a gene located in a region of chromosome 22 known to be associated with schizophrenia.

"The fact that the mutations are all from different genes is particularly fascinating,” lead researcher Maria Karayiorgou of Columbia University in New York told the BBC. "It suggests that many more mutations than we suspected may contribute to schizophrenia."

The reason so many different genes carried new mutations likely stems from the fact that the disease is so complex and involves a variety of genetic pathways, providing a large target for mutations. This, combined with the high rate of mutations that affected protein structure and function, could explain why the disease is so common, affecting about one in every 100 people, the authors said.

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Avatar of: Addy Hengle

Addy Hengle

Posts: 1457

August 9, 2011

Wide words!I do agree with you.Golfcheapclubs.com offers cheap golf clubs

Avatar of: Mabrouk99

Anonymous

August 9, 2011

This finding is interesting and it may points to the role of genotype X environment interactions in causing mutations related to schizophrenia. Life style should be investigated in this case... 

Avatar of:

Posts: 0

August 9, 2011

Wide words!I do agree with you.Golfcheapclubs.com offers cheap golf clubs

Avatar of:

Posts: 0

August 9, 2011

This finding is interesting and it may points to the role of genotype X environment interactions in causing mutations related to schizophrenia. Life style should be investigated in this case... 

Avatar of:

Posts: 0

August 9, 2011

Wide words!I do agree with you.Golfcheapclubs.com offers cheap golf clubs

Avatar of:

Posts: 0

August 9, 2011

This finding is interesting and it may points to the role of genotype X environment interactions in causing mutations related to schizophrenia. Life style should be investigated in this case... 

Avatar of:

Posts: 0

August 11, 2011

There are many established gene-environment interactions in the etiology of schizophrenia. Lifestyle has also been investigated for decades, and contributing factors such as drug and alcohol abuse, omega 3 and iron deficiency, urbanisation are among the list.. Look at twin and adoptive studies where environment and lifestyle contributed to the developemt of psychosis in one and not the other..

Avatar of:

Posts: 0

August 11, 2011

LF,

Your informative feedbacks on my (by Mabrouk99) previous comments on gentotype-environment interactions as related to schizophrenia development were appreciated and warranted. Thanks,, M. A. El-Sharkawy.

Avatar of:

Posts: 0

August 11, 2011

There are many established gene-environment interactions in the etiology of schizophrenia. Lifestyle has also been investigated for decades, and contributing factors such as drug and alcohol abuse, omega 3 and iron deficiency, urbanisation are among the list.. Look at twin and adoptive studies where environment and lifestyle contributed to the developemt of psychosis in one and not the other..

Avatar of:

Posts: 0

August 11, 2011

LF,

Your informative feedbacks on my (by Mabrouk99) previous comments on gentotype-environment interactions as related to schizophrenia development were appreciated and warranted. Thanks,, M. A. El-Sharkawy.

Avatar of: LF

Anonymous

August 11, 2011

There are many established gene-environment interactions in the etiology of schizophrenia. Lifestyle has also been investigated for decades, and contributing factors such as drug and alcohol abuse, omega 3 and iron deficiency, urbanisation are among the list.. Look at twin and adoptive studies where environment and lifestyle contributed to the developemt of psychosis in one and not the other..

Avatar of: Mabrouk A. El-Sharkawy

Anonymous

August 11, 2011

LF,

Your informative feedbacks on my (by Mabrouk99) previous comments on gentotype-environment interactions as related to schizophrenia development were appreciated and warranted. Thanks,, M. A. El-Sharkawy.

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