The Seat of Memory

Early on, researchers had learned that the hippocampus was the structure in the brain where long-term memories were created and stored, but it was not known whether the different cell types within this structure might be more or less susceptible to the aging process.

By | September 1, 2011

Infographic: The Seat of Memory
View full size JPG | PDF
TAMI TOLPA

Early on, researchers had learned that the hippocampus was the structure in the brain where long-term memories were created and stored, but it was not known whether the different cell types within this structure might be more or less susceptible to the aging process. Using a number of methods, we showed that the cells of the dentate gyrus­—which receives incoming signal from other parts of the brain—were less active in old brains than they were in young ones. In general, the lower the activity in the dentate gyrus was, the poorer a rat’s ability to store memory.  These results contrasted with Alzheimer’s disease patients, whose CA1 cells and entorhinal cortex region are most dram­atically affected, allowing us to demonstrate a clear difference between changes r­elated to normal aging and those seen in age-related disease.

Read the full story.

Add a Comment

Avatar of: You

You

Processing...
Processing...

Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo

Popular Now

  1. Top 10 Innovations 2016
    Features Top 10 Innovations 2016

    This year’s list of winners celebrates both large leaps and small (but important) steps in life science technology.

  2. Gut Microbes Linked to Neurodegenerative Disease
  3. Pubic Hair Grooming Linked to STI Risk
    The Nutshell Pubic Hair Grooming Linked to STI Risk

    Observational study suggests pubic hair grooming correlates with heightened risk of acquiring sexually transmitted infections, although causation remains unclear.

  4. Naive T Cells Find Homes in Lymphoid Tissue
Rockland