The Seat of Memory

Early on, researchers had learned that the hippocampus was the structure in the brain where long-term memories were created and stored, but it was not known whether the different cell types within this structure might be more or less susceptible to the aging process.

By | September 1, 2011

Infographic: The Seat of Memory
View full size JPG | PDF
TAMI TOLPA

Early on, researchers had learned that the hippocampus was the structure in the brain where long-term memories were created and stored, but it was not known whether the different cell types within this structure might be more or less susceptible to the aging process. Using a number of methods, we showed that the cells of the dentate gyrus­—which receives incoming signal from other parts of the brain—were less active in old brains than they were in young ones. In general, the lower the activity in the dentate gyrus was, the poorer a rat’s ability to store memory.  These results contrasted with Alzheimer’s disease patients, whose CA1 cells and entorhinal cortex region are most dram­atically affected, allowing us to demonstrate a clear difference between changes r­elated to normal aging and those seen in age-related disease.

Read the full story.

Advertisement

Add a Comment

Avatar of: You

You

Processing...
Processing...

Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo

Popular Now

  1. Next Generation: Nanotube Scaffolds Reconnect Spinal Neurons
  2. Mapping the Human Connectome
    Daily News Mapping the Human Connectome

    A new map of human cortex combines data from multiple imaging modalities and comprises 180 distinct regions.

  3. Will Organs-in-a-Dish Ever Replace Animal Models?
  4. Your Office Has a Distinct Microbiome
RayBiotech