Advertisement

The Cytokine Cycle

The initiating cause of Alzheimer’s disease is still unknown. However, from our studies it’s clear that many types of neuronal damage—­­from traumatic brain injury, to epilepsy, infection, or genetic predisposition—­can activate brain immune cells—microglia and astrocytes-- promoting them to produce IL-1 and S100 inflammatory cytokines.

By | September 1, 2011

Infographic: The Cytokine Cycle
View full size JPG | PDF
LUCY READING-IKKANDA

The initiating cause of Alzheimer’s disease is still unknown. However, from our studies it’s clear that many types of neuronal damage—­­from traumatic brain injury, to epilepsy, infection, or genetic predisposition—­can activate brain immune cells—­­microglia and astrocytes—­­prompting them to produce IL-1 and S100 inflammatory cytokines. Initially, activated microglia can help clear dead neurons, but when activated repeatedly, their IL-1 production increases, feeding a cycle of damage-responses, each of which is characteristic of Alzheimer’s, and many of which in turn activate more IL-1 production.

Read the full story.

Advertisement

Add a Comment

Avatar of: You

You

Processing...
Processing...

Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo

Comments

Avatar of: Dianne

Anonymous

September 20, 2011

Very interesting and well illustrated. However the link to the full story is not working.

Avatar of:

Posts: 0

September 20, 2011

Very interesting and well illustrated. However the link to the full story is not working.

Avatar of:

Posts: 0

September 20, 2011

Very interesting and well illustrated. However the link to the full story is not working.

Avatar of:

Posts: 0

September 22, 2011

Would love to read the full story as the graphic is great, please fix the link!

Avatar of:

Posts: 0

September 22, 2011

Thank you both for pointing out the broken link. It has been fixed.

Thanks for reading!
~Jef Akst, editor, The Scientist

Avatar of:

Posts: 0

September 22, 2011

Thank you Jef- greatly appreciated! It is such a fascinating and important area of research.

Avatar of:

Posts: 0

September 22, 2011

Would love to read the full story as the graphic is great, please fix the link!

Avatar of:

Posts: 0

September 22, 2011

Thank you both for pointing out the broken link. It has been fixed.

Thanks for reading!
~Jef Akst, editor, The Scientist

Avatar of:

Posts: 0

September 22, 2011

Thank you Jef- greatly appreciated! It is such a fascinating and important area of research.

Avatar of: Tracy

Anonymous

September 22, 2011

Would love to read the full story as the graphic is great, please fix the link!

Avatar of: TheSciAdmin

TheSciAdmin

Posts: 56

September 22, 2011

Thank you both for pointing out the broken link. It has been fixed.

Thanks for reading!
~Jef Akst, editor, The Scientist

Avatar of: Dianne

Anonymous

September 22, 2011

Thank you Jef- greatly appreciated! It is such a fascinating and important area of research.

Advertisement

Popular Now

  1. Opinion: Too Many Mitochondrial Genome Papers
  2. Antibiotics and the Gut Microbiome
  3. Sex Differences in Pain Pathway
  4. The Sum of Our Parts
    Features The Sum of Our Parts

    Putting the microbiome front and center in health care, in preventive strategies, and in health-risk assessments could stem the epidemic of noncommunicable diseases.

Advertisement
Eppendorf
Eppendorf
Advertisement
The Scientist