Though doctors often deem older patients unfit to receive chemotherapy, a recent trial showed that patients at a median of 74 could tolerate combination therapy for colorectal cancer, suggesting that with careful oversight, this age group can be enrolled in clinical trials and be treated with more aggressive drugs.
M.T. Seymour et al., "Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial," Lancet, 377:1749-59, 2011. Free F1000 Evaluation
Helicobacter pylori, a bacterium associated with ulcers that routinely colonizes the gut, appears to prevent the development of asthma by stimulating the production of regulatory T cells.
Confirming studies in mice, researchers showed that a mother's low consumption of carbohydrates during pregnancy increases methylation of a specific site on her child's DNA that is associated with increased fat mass by age 9.
By testing the hearts of old mice for oxidative agents in mitochondria, researchers found that acrolein, a chemical found in cooked fatty foods and car exhaust, caused most of the damage to proteins in aged cells.
J.D. Chavez et al., "Site-specific proteomic analysis of lipoxidation adducts in cardiac mitochondria reveals chemical diversity of 2-alkenal adduction," J Proteomics. doi:10.1016/j.jprot.2011.03.031, 2011. Free F1000 Evaluation
Old flies lose the signaling ability of their FOXO transcription factor, which removes damaged proteins from muscle fibers. Restoring FOXO signaling not only improved muscle strength, but also increased lifespan, demonstrating a link between muscoskeletal health and longevity.
A review of a million cataract surgeries in Sweden shows that the procedure has become more widely used with fewer side effects.
Mapping the brains of 5-32 year olds, researchers noted that white matter increases as gray matter decreases with age, providing a baseline against which neurological developmental disorders can be compared.
The F1000 Top 7 is a snapshot of the highest ranked articles on aging from a 30-day period on Faculty of 1000, as calculated on September 8, 2011. Faculty Members evaluate and rate the most important papers in their field. To see the latest rankings, search the database, and read daily evaluations, visit http://f1000.com.