Advertisement

MicroRNAs Prevent Cell Reprogramming

A group of microRNAs can inhibit the formation of induced pluripotent stem cells, and may provide a target for more efficient reprogramming of somatic cells.

By | October 24, 2011

WELLCOME IMAGES, STEPHEN ELLIMAN

A group of microRNAs known as miR-34 miRNAs prevent the reprogramming of cells by inhibiting pluripotency-associated genes, a new study published yesterday (October 23) in Nature Cell Biology has found. The findings suggest that blocking miR-34 miRNAs may lead to more efficient reprogramming of somatic cells into induced pluripotent stem cells (iPSCs).

MiR-34 production is regulated by the tumor suppressor protein p53—which is known to repress reprogramming, and thus iPSC generation, by modulating the expression of several pluripotency-associated genes. Researchers found that MiR-34 miRNAs repress somatic cell reprogramming by inhibiting some of the pluripotency-associated genes downstream of p53.

 

Advertisement

Add a Comment

Avatar of: You

You

Processing...
Processing...

Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo
Advertisement

Popular Now

  1. Opinion: Making Progress by Slowing Down
  2. Influential Cancer Biologist Dies
  3. Censored Professor Quits
    The Nutshell Censored Professor Quits

    Alice Dreger is resigning from the faculty of Northwestern University, claiming that the administration censored her work in a faculty journal.

  4. How Fats Influence the Microbiome
Advertisement
Cell Sciences
Cell Sciences
Advertisement
Life Technologies