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Mom’s Versus Dad’s BRCA

The age at which BRCA carriers are diagnosed with breast cancer may depend on which parent contributed the mutation.

By | December 13, 2011

image: Mom’s Versus Dad’s BRCA stock.xchng, ngould

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Whether a BRCA mutation is inherited from the mother or father may affect age of diagnosis or even the risk of developing cancer in the carrier, researchers presented at the San Antonio Breast Cancer Symposium last week. After analyzing 1,889 breast or ovarian cancer patients at the Monter Cancer Center in Lake Success, NY—130 of which knew the parent of origin of either their BRCA1 or BRCA2 mutation—the researchers found that the patients were diagnosed 6 to 9 years earlier if the mutation was passed down by the father.

“Genetic diseases may display parent-of-origin effects,” Iuliana Shapira, director of cancer genetics at the Monter Cancer Center said in a press release. “Cancer penetrance in mutations carriers may be determined by the parent origin of BRCA mutation.”

If the findings are corroborated by larger cohort studies, Shapira said, they may influence treatment and preventative measures, such as the age at which carriers of BRCA mutations opt for surgical removal of breasts and ovaries. “Doctors might think about watching and waiting in young women with BRCA mutations inherited from her mother’s family and being more aggressive in young women who inherited the mutation from their father’s side,” she said.

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Comments

Avatar of: Barry Barclay

Barry Barclay

Posts: 1457

December 13, 2011

While it is good news that BRCA1 carriers might be diagnosed earlier by this new finding the sad fact remains that we have little to offer this patient population clinically besides drastic surgical intervention in otherwise healthy young women. Once diagnosed with a BRCA1 mutation in the age of genomic medicine surely to goodness there is a better option than this type of surgery. We need much more research effort spent to find ways to regularly monitor these women by safe and effective means and to diagnose and treat very early breast and ovarian cancers in this high-risk population. We should strive much more vigorously to successfully diagnose and treat very early disease and to rely on prophylactic removal of healthy breasts and ovaries for as short a period as possible as an acceptable first line procedure.

Avatar of: Audrey Ciccone

Audrey Ciccone

Posts: 1457

December 13, 2011

Very interesting outcome.  My mother inherited her gene from her father and is still cancer free at 70 along with her 77 year old brother who also has the BRCA1 mutation.  Only my sister has developed an early onset cancer - after inheriting it from our mother.

Avatar of:

Posts: 0

December 13, 2011

While it is good news that BRCA1 carriers might be diagnosed earlier by this new finding the sad fact remains that we have little to offer this patient population clinically besides drastic surgical intervention in otherwise healthy young women. Once diagnosed with a BRCA1 mutation in the age of genomic medicine surely to goodness there is a better option than this type of surgery. We need much more research effort spent to find ways to regularly monitor these women by safe and effective means and to diagnose and treat very early breast and ovarian cancers in this high-risk population. We should strive much more vigorously to successfully diagnose and treat very early disease and to rely on prophylactic removal of healthy breasts and ovaries for as short a period as possible as an acceptable first line procedure.

Avatar of:

Posts: 0

December 13, 2011

Very interesting outcome.  My mother inherited her gene from her father and is still cancer free at 70 along with her 77 year old brother who also has the BRCA1 mutation.  Only my sister has developed an early onset cancer - after inheriting it from our mother.

Avatar of:

Posts: 0

December 13, 2011

While it is good news that BRCA1 carriers might be diagnosed earlier by this new finding the sad fact remains that we have little to offer this patient population clinically besides drastic surgical intervention in otherwise healthy young women. Once diagnosed with a BRCA1 mutation in the age of genomic medicine surely to goodness there is a better option than this type of surgery. We need much more research effort spent to find ways to regularly monitor these women by safe and effective means and to diagnose and treat very early breast and ovarian cancers in this high-risk population. We should strive much more vigorously to successfully diagnose and treat very early disease and to rely on prophylactic removal of healthy breasts and ovaries for as short a period as possible as an acceptable first line procedure.

Avatar of:

Posts: 0

December 13, 2011

Very interesting outcome.  My mother inherited her gene from her father and is still cancer free at 70 along with her 77 year old brother who also has the BRCA1 mutation.  Only my sister has developed an early onset cancer - after inheriting it from our mother.

Avatar of:

Posts: 0

December 28, 2011

Dear All,

We do BRCA 1 and 2 test
www.srl.in
http://www.srl.in/pathology/fi...
09629925522-Chennai

Avatar of:

Posts: 0

December 28, 2011

Dear All,

We do BRCA 1 and 2 test
www.srl.in
http://www.srl.in/pathology/fi...
09629925522-Chennai

Avatar of: Biotech Gita

Biotech Gita

Posts: 1

December 28, 2011

Dear All,

We do BRCA 1 and 2 test
www.srl.in
http://www.srl.in/pathology/fi...
09629925522-Chennai

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