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Determining mRNA Survival

Researchers uncover a self-destruct mechanism that determines the lifespan of messenger RNA molecules.

By | December 23, 2011

image: Determining mRNA Survival Wikimedia Commons, Tom Ellenberger

WIKIMEDIA COMMONS, TOM ELLENBERGER

Observing single molecules in yeast cells in real time, researchers have discovered that the promoter regions of two genes involved in the cell cycle not only act to encourage transcription; they also initiate a self-destruct timer that controls when the resulting messenger RNA (mRNA) molecules are degraded. The results, published today (December 22) in Cell, provide some of the first clues regarding how cells manage their mRNA levels, and could have implications for controlling cell division in cancer.

“Our findings indicate that genes making proteins whose levels must be carefully controlled contain promoter regions that sentence their mRNA molecules to death even as the mRNA is being born,” senior author Robert Singer of the Gruss Lipper Biophotonics Center and Albert Einstein College of Medicine of Yeshiva University said in a press release. “Their lifespans are determined at the moment of their birth.”

Specifically, the promoter regions of SWI5 and CLB2—both genes critical for regulating the cell cycle—recruit a protein called Dbf2p to jump onto the mRNAs during transcription. In the cytoplasm, another protein, called Dbf20p, joins Dbf2p, essentially tagging the mRNA for destruction.

Due to SWI5 and CLB2’s involvement in the cell cycle, the results could be relevant for developing anti-cancer therapeutics, Singer said. “Once you gain insight into the mechanisms controlling the cell cycle and cell division, you can propose targeted therapies for regulating the uncontrolled cell division that characterizes cancer.”

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Comments

Avatar of: Bruce Dogg

Bruce Dogg

Posts: 5

January 2, 2012

Makes you wonder if this may also have a roll to play in human longevity in general. Working out how and why cells die in general or making them replicate perfectly is probably one of the most important human goals of the next century.

Avatar of:

Posts: 0

January 2, 2012

Makes you wonder if this may also have a roll to play in human longevity in general. Working out how and why cells die in general or making them replicate perfectly is probably one of the most important human goals of the next century.

Avatar of:

Posts: 0

January 2, 2012

Makes you wonder if this may also have a roll to play in human longevity in general. Working out how and why cells die in general or making them replicate perfectly is probably one of the most important human goals of the next century.

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