Longevity Study Lives On

A reanalysis of the study reporting genes linked to extremely long life, which was retracted from Science last summer, is published in PLoS ONE.

By | January 24, 2012

image: Longevity Study Lives On Dreamstime, Melinda Nagy

DREAMSTIME, MELINDA NAGY

The research team that retracted a Science paper reporting a genetic signature for extreme longevity has published a re-analysis of the original results. While the new study took a fresh look at the genes of the original subjects, which included around 1,000 elderly people over 90 years old and 1,200 controls, it also included a new cohort of 60 individuals with a median age of 107, according to the new report published last week in PLoS ONE. This time the team found a group of 281 gene variants that predicted the likelihood of becoming a centenarian with around 60 percent accuracy in some cohorts.

The original Science paper, published in July 2010, claimed to have identified 19 genes that predicted extreme longevity with 77 percent accuracy. However, the authors retracted the paper a year later after critics discredited the results due to inadequate controls and flaws in the gene sequencing chip used.

"We made a mistake," Boston University biostatistician and author on both papers Paola Sebastiani, told ScienceNOW. "At the same time, we continue to believe this is a good paper."

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Avatar of: Dov

Dov

Posts: 1457

January 26, 2012

Genetics And Cultur, Genes Or Way-Of-Life
-----------------------------------------
(bigbrains, culturegenetics, lifeevolution)
 
October 19, 2011 On Bigger Human Brain, Horse And Wagon A.Change during human evolution could have led to bigger brains.http://www.sciencenews.org/view/gener... Genes, New Brainhttp://the-scientist.com/... B.On Culture And Genetics, Horses And Wagonhttp://universe-life.com/... you saw it once, you saw it a million times: it’s the horses pulling, not the wagon pushing ! C.Enough with the AAAS trade-union mandated science peer-review ignorance. It’s culture that modifies genetics, not genetics that modifies culture. Dov Henis (comments from 22nd century)
 

Avatar of:

Posts: 0

January 26, 2012

Genetics And Cultur, Genes Or Way-Of-Life
-----------------------------------------
(bigbrains, culturegenetics, lifeevolution)
 
October 19, 2011 On Bigger Human Brain, Horse And Wagon A.Change during human evolution could have led to bigger brains.http://www.sciencenews.org/view/gener... Genes, New Brainhttp://the-scientist.com/... B.On Culture And Genetics, Horses And Wagonhttp://universe-life.com/... you saw it once, you saw it a million times: it’s the horses pulling, not the wagon pushing ! C.Enough with the AAAS trade-union mandated science peer-review ignorance. It’s culture that modifies genetics, not genetics that modifies culture. Dov Henis (comments from 22nd century)
 

Avatar of:

Posts: 0

January 26, 2012

Genetics And Cultur, Genes Or Way-Of-Life
-----------------------------------------
(bigbrains, culturegenetics, lifeevolution)
 
October 19, 2011 On Bigger Human Brain, Horse And Wagon A.Change during human evolution could have led to bigger brains.http://www.sciencenews.org/view/gener... Genes, New Brainhttp://the-scientist.com/... B.On Culture And Genetics, Horses And Wagonhttp://universe-life.com/... you saw it once, you saw it a million times: it’s the horses pulling, not the wagon pushing ! C.Enough with the AAAS trade-union mandated science peer-review ignorance. It’s culture that modifies genetics, not genetics that modifies culture. Dov Henis (comments from 22nd century)
 

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