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Horizon Discovery
Horizon Discovery

A Mammalian Longevity Gene?

Researchers find the first evidence that a sirtuin gene prolongs life in mice.

By | February 23, 2012

FLICKR, NEWTOWN GRAFITTI

In 2001, researchers showed that a sirtuin protein—associated with the cellular stress response and metabolism—was essential for slowing aging in yeast. Now, researchers at Bar-Ilan University in Ramat-Gan, Israel, found that a different member of the sirtuin family may stall death in mice, suggesting sirtuins may also be significant players in mammalian aging.

A couple of years ago, sirtuin 1 (SIRT1) became the focus of attention in aging research because it was the gene that most closely resembled the yeast gene linked to longevity. In 2008, pharmaceutical giant GlaxoSmithKline paid $270 million for a biotech company that was searching for compounds that activated SIRT1, according to Nature. But evidence for SIRT1’s role in expanding lifespan in humans has been hard to come by, and research showing its longevity effects in fruit flies has been questioned.

Instead, researchers at Bar-Ilan looked turned their focus to sirtuin 6 (SIRT6), which in 2006 was shown to speed death in mice lacking the gene. Here they showed that, at least in male mice, overexpression of the SIRT6 extended lifespan by nearly 16 percent. However, other researchers question whether the increase in lifespan is really due to improved longevity, which is associated with improved memory and mobility, or rather a result of anti-cancer or improved metabolic effects, reported Nature.

 

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Avatar of: Dov

Dov

Posts: 1457

February 23, 2012

Genes’ Expressions Are Results Of Life Culture, NOT Their Cause
 
Long-lived people distinguished by DNAâ€쳌? Ludicrous…The "long life" DNA expressions are formed by the living mode-culture of the old timers, by the genes “adaptingâ€쳌 to their “desirableâ€쳌 circumstances. This is evolution, natural selection, and the genes ARE ORGANISMS.It's the culture horses that pull-effect the genetic changes, NOT "longevity genes wagon" that pushes-effects long life.Ask Pavlov. Learn from him...Dov Henis (comments from 22nd century)http://universe-life.com/2011/...
 
 
Ludicrous Ignorant Concepts-Understanding Of Culture-Genetics  Life-Aging
“Longevity Genesâ€쳌 Are Expressions Effected By The Life Mode, Culture,  Of The Aged
It’s  Culture That Modifies Genes, NOT Vice Versa
 
A.
http://news.sciencemag.org/sci...
 
http://news.sciencemag.org/sci...
 
B.
"To Map Cell Circuits" with ludicrous ignorant concepts-understanding of what is life, cell...!
Quantum Mechanics Of Life                                                                                                                                                                      
 http://universe-life.com/2011/...
 
Life’s Evolution Is The Quantum Mechanics Of Biology
From “Essence Of Quantum Mechanicsâ€쳌http://universe-life.com/2011/...
 
The universe, and life within it, are not just conglomerations of mechanisms. The universe, and life within it, have come into being by the nature of energy-mass dualism, and their fate, their final outcome, is governed by this dualism. The genesis and, most probable cyclic, existence of the universe are governed by the energy-mass relationship.
Energy-mass relationship governs also the routes, the mechanisms, of cosmic and life evolutions.
Mechanisms do not set/determine the classical physics fate states. Mechanisms are routes of evolution between classical physics fate states. Quantum mechanics are mechanisms, probable, possible and actual mechanisms of getting from one to other classical physics states WITHIN the expanse from cosmic singularity to the maximum expanded universe and back to singularity states.
The universe is the archetype of quantum within classical physics. This is the fractal oneness of the universe. Astronomically there are two physics. A classical Newtonian physics behavior of and between galactic clusters, and a quantum physics behavior WITHIN the galactic clusters.
 
Life’s Evolution Is The Quantum Mechanics Of Biology.UNRAVEL COMPLEXITIES OF GENETICS.                                                                                                                                              
 Extend Evolution/Natural Selection Backward To Life’s Primal Organisms, RNA Genes, And To Genomes, BOTH ARE ORGANISMs, evolving adapting by culture, by reactions to circumstances.
 
The origin-reason and the purpose-fate of life are mechanistic, ethically and practically valueless. Life is the cheapest commodity on Earth.
Human life is just one of many nature’s routes for the natural survival of RNAs, the base Earth organism.
It is up to humans themselves to elect the purpose and format of their life as individuals and as group-members.
 
Dov Henis                                                                                                                                                                                                        
 (Comments From 22nd Century)
“Rethink Evolution/Natural Selectionâ€쳌http://darwiniana.com/2011/03/...

Avatar of:

Posts: 0

February 23, 2012

Genes’ Expressions Are Results Of Life Culture, NOT Their Cause
 
Long-lived people distinguished by DNAâ€쳌? Ludicrous…The "long life" DNA expressions are formed by the living mode-culture of the old timers, by the genes “adaptingâ€쳌 to their “desirableâ€쳌 circumstances. This is evolution, natural selection, and the genes ARE ORGANISMS.It's the culture horses that pull-effect the genetic changes, NOT "longevity genes wagon" that pushes-effects long life.Ask Pavlov. Learn from him...Dov Henis (comments from 22nd century)http://universe-life.com/2011/...
 
 
Ludicrous Ignorant Concepts-Understanding Of Culture-Genetics  Life-Aging
“Longevity Genesâ€쳌 Are Expressions Effected By The Life Mode, Culture,  Of The Aged
It’s  Culture That Modifies Genes, NOT Vice Versa
 
A.
http://news.sciencemag.org/sci...
 
http://news.sciencemag.org/sci...
 
B.
"To Map Cell Circuits" with ludicrous ignorant concepts-understanding of what is life, cell...!
Quantum Mechanics Of Life                                                                                                                                                                      
 http://universe-life.com/2011/...
 
Life’s Evolution Is The Quantum Mechanics Of Biology
From “Essence Of Quantum Mechanicsâ€쳌http://universe-life.com/2011/...
 
The universe, and life within it, are not just conglomerations of mechanisms. The universe, and life within it, have come into being by the nature of energy-mass dualism, and their fate, their final outcome, is governed by this dualism. The genesis and, most probable cyclic, existence of the universe are governed by the energy-mass relationship.
Energy-mass relationship governs also the routes, the mechanisms, of cosmic and life evolutions.
Mechanisms do not set/determine the classical physics fate states. Mechanisms are routes of evolution between classical physics fate states. Quantum mechanics are mechanisms, probable, possible and actual mechanisms of getting from one to other classical physics states WITHIN the expanse from cosmic singularity to the maximum expanded universe and back to singularity states.
The universe is the archetype of quantum within classical physics. This is the fractal oneness of the universe. Astronomically there are two physics. A classical Newtonian physics behavior of and between galactic clusters, and a quantum physics behavior WITHIN the galactic clusters.
 
Life’s Evolution Is The Quantum Mechanics Of Biology.UNRAVEL COMPLEXITIES OF GENETICS.                                                                                                                                              
 Extend Evolution/Natural Selection Backward To Life’s Primal Organisms, RNA Genes, And To Genomes, BOTH ARE ORGANISMs, evolving adapting by culture, by reactions to circumstances.
 
The origin-reason and the purpose-fate of life are mechanistic, ethically and practically valueless. Life is the cheapest commodity on Earth.
Human life is just one of many nature’s routes for the natural survival of RNAs, the base Earth organism.
It is up to humans themselves to elect the purpose and format of their life as individuals and as group-members.
 
Dov Henis                                                                                                                                                                                                        
 (Comments From 22nd Century)
“Rethink Evolution/Natural Selectionâ€쳌http://darwiniana.com/2011/03/...

Avatar of:

Posts: 0

February 24, 2012

Genes’ Expressions Are Results Of Life Culture, NOT Their Cause
 
Long-lived people distinguished by DNAâ€쳌? Ludicrous…The "long life" DNA expressions are formed by the living mode-culture of the old timers, by the genes “adaptingâ€쳌 to their “desirableâ€쳌 circumstances. This is evolution, natural selection, and the genes ARE ORGANISMS.It's the culture horses that pull-effect the genetic changes, NOT "longevity genes wagon" that pushes-effects long life.Ask Pavlov. Learn from him...Dov Henis (comments from 22nd century)http://universe-life.com/2011/...
 
 
Ludicrous Ignorant Concepts-Understanding Of Culture-Genetics  Life-Aging
“Longevity Genesâ€쳌 Are Expressions Effected By The Life Mode, Culture,  Of The Aged
It’s  Culture That Modifies Genes, NOT Vice Versa
 
A.
http://news.sciencemag.org/sci...
 
http://news.sciencemag.org/sci...
 
B.
"To Map Cell Circuits" with ludicrous ignorant concepts-understanding of what is life, cell...!
Quantum Mechanics Of Life                                                                                                                                                                       
 http://universe-life.com/2011/...
 
Life’s Evolution Is The Quantum Mechanics Of Biology
From “Essence Of Quantum Mechanicsâ€쳌http://universe-life.com/2011/...
 
The universe, and life within it, are not just conglomerations of mechanisms. The universe, and life within it, have come into being by the nature of energy-mass dualism, and their fate, their final outcome, is governed by this dualism. The genesis and, most probable cyclic, existence of the universe are governed by the energy-mass relationship.
Energy-mass relationship governs also the routes, the mechanisms, of cosmic and life evolutions.
Mechanisms do not set/determine the classical physics fate states. Mechanisms are routes of evolution between classical physics fate states. Quantum mechanics are mechanisms, probable, possible and actual mechanisms of getting from one to other classical physics states WITHIN the expanse from cosmic singularity to the maximum expanded universe and back to singularity states.
The universe is the archetype of quantum within classical physics. This is the fractal oneness of the universe. Astronomically there are two physics. A classical Newtonian physics behavior of and between galactic clusters, and a quantum physics behavior WITHIN the galactic clusters.
 
Life’s Evolution Is The Quantum Mechanics Of Biology.UNRAVEL COMPLEXITIES OF GENETICS.                                                                                                                                             
 Extend Evolution/Natural Selection Backward To Life’s Primal Organisms, RNA Genes, And To Genomes, BOTH ARE ORGANISMs, evolving adapting by culture, by reactions to circumstances.
 
The origin-reason and the purpose-fate of life are mechanistic, ethically and practically valueless. Life is the cheapest commodity on Earth.
Human life is just one of many nature’s routes for the natural survival of RNAs, the base Earth organism.
It is up to humans themselves to elect the purpose and format of their life as individuals and as group-members.
 
Dov Henis                                                                                                                                                                                                        
 (Comments From 22nd Century)
“Rethink Evolution/Natural Selectionâ€쳌http://darwiniana.com/2011/03/...

Avatar of: Dov

Dov

Posts: 1457

February 24, 2012

Genes’ Expressions Are Results Of Life Culture, NOT Their Cause
 
Long-lived people distinguished by DNAâ€쳌? Ludicrous…The "long life" DNA expressions are formed by the living mode-culture of the old timers, by the genes “adaptingâ€쳌 to their “desirableâ€쳌 circumstances. This is evolution, natural selection, and the genes ARE ORGANISMS.It's the culture horses that pull-effect the genetic changes, NOT "longevity genes wagon" that pushes-effects long life.Ask Pavlov. Learn from him...Dov Henis (comments from 22nd century)http://universe-life.com/2011/...
 
 
Ludicrous Ignorant Concepts-Understanding Of Culture-Genetics  Life-Aging
“Longevity Genesâ€쳌 Are Expressions Effected By The Life Mode, Culture,  Of The Aged
It’s  Culture That Modifies Genes, NOT Vice Versa
 
A.
http://news.sciencemag.org/sci...
 
http://news.sciencemag.org/sci...
 
B.
"To Map Cell Circuits" with ludicrous ignorant concepts-understanding of what is life, cell...!
Quantum Mechanics Of Life                                                                                                                                                                       
 http://universe-life.com/2011/...
 
Life’s Evolution Is The Quantum Mechanics Of Biology
From “Essence Of Quantum Mechanicsâ€쳌http://universe-life.com/2011/...
 
The universe, and life within it, are not just conglomerations of mechanisms. The universe, and life within it, have come into being by the nature of energy-mass dualism, and their fate, their final outcome, is governed by this dualism. The genesis and, most probable cyclic, existence of the universe are governed by the energy-mass relationship.
Energy-mass relationship governs also the routes, the mechanisms, of cosmic and life evolutions.
Mechanisms do not set/determine the classical physics fate states. Mechanisms are routes of evolution between classical physics fate states. Quantum mechanics are mechanisms, probable, possible and actual mechanisms of getting from one to other classical physics states WITHIN the expanse from cosmic singularity to the maximum expanded universe and back to singularity states.
The universe is the archetype of quantum within classical physics. This is the fractal oneness of the universe. Astronomically there are two physics. A classical Newtonian physics behavior of and between galactic clusters, and a quantum physics behavior WITHIN the galactic clusters.
 
Life’s Evolution Is The Quantum Mechanics Of Biology.UNRAVEL COMPLEXITIES OF GENETICS.                                                                                                                                             
 Extend Evolution/Natural Selection Backward To Life’s Primal Organisms, RNA Genes, And To Genomes, BOTH ARE ORGANISMs, evolving adapting by culture, by reactions to circumstances.
 
The origin-reason and the purpose-fate of life are mechanistic, ethically and practically valueless. Life is the cheapest commodity on Earth.
Human life is just one of many nature’s routes for the natural survival of RNAs, the base Earth organism.
It is up to humans themselves to elect the purpose and format of their life as individuals and as group-members.
 
Dov Henis                                                                                                                                                                                                        
 (Comments From 22nd Century)
“Rethink Evolution/Natural Selectionâ€쳌http://darwiniana.com/2011/03/...

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