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Transplant Without Drugs?

A new method for transplanting immunologically mismatched organs may remove the need for life-long immunosuppressive drugs to prevent rejection.

By | March 8, 2012

Organ transplantationWIKIMEDIA COMMONS, ESPA1010

Researchers at the University of Louisville in Kentucky found a way to trick the body of a mismatched organ-transplant recipient into thinking that the organ is a perfect match, in a study published this week in Science Translational Medicine.

Previous studies attempted to get the same effect by injecting some of the donor’s bone marrow, which contains blood stem cells that create new immune cells that would recognize the donor organ as self , into the recipient, reported Nature. After removing the bulk of the recipient’s native immune cells with radiation and chemotherapy, the donor’s bone marrow would be injected and repopulate the immune system with immune cells that would tolerate the new organs. The approach had some success in the clinic, although not all patients benefitted in the long term.

Instead of using donor cells, University of Louisville researchers created a cocktail of engineered blood stem cells, in addition to a novel type of immune cell they discovered called facilitating cells, which they plan to commercialize through a company called Regenerex.  Five of the eight recipients were successfully weaned off their immunosuppressants a year after their operations, and none of the patients had antibodies against the new organ, suggesting the organ was not being rejected.

Will the patients manage to keep their new organs without immunosuppression in the long term? “You would hope that it’s true, but it’s a little early to claim that,” David Sachs, director of the Transplantation Biology Research Center at Massachusetts General Hospital told Nature.

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Comments

Avatar of: eghanem

eghanem

Posts: 1

March 8, 2012

Well, the idea is really innovative.. but the BIG problem lies in controlling the donor's  immune cells in attacking/producing Abs against the patient's old organs!! 

Avatar of: Edward R. Mikol

Edward R. Mikol

Posts: 1457

March 8, 2012

Until pluripotent cells of our own can be coaxed into growing perfectly matched replacement organs this seems like a brilliant method of integrating the alien parts and hopefully succeeds in removing the burden of immunosuppressant therapy.

Avatar of:

Posts: 0

March 8, 2012

Well, the idea is really innovative.. but the BIG problem lies in controlling the donor's  immune cells in attacking/producing Abs against the patient's old organs!! 

Avatar of:

Posts: 0

March 8, 2012

Until pluripotent cells of our own can be coaxed into growing perfectly matched replacement organs this seems like a brilliant method of integrating the alien parts and hopefully succeeds in removing the burden of immunosuppressant therapy.

Avatar of:

Posts: 0

March 9, 2012

*Altough I know my lyre is doomed to sound in vain

Around your fudden reason, soaked in the vices'
rain.*

(Depraved youths - Mihai Eminescu)

 

When the scientist will
recognize the Adam mtDNA theory then he will understand how the nature and
condition of the sternal marrow is essential in establishing the final
diagnosis of the disease and he will understand that *The word of God is alive
and active, sharper than any double-edged sword. It cuts all the way through,
to where soul and spirit meet, to where joints and marrow come together. It
judges the desires and thoughts of man's heart.* (Bible,
Paul, Hebrew 4.12)

 

I have developed five years ago a new
theory on the paternal mitochondrial DNA inheritance that brings scientific
arguments and *new perspectives regarding the nature and origin of
biological information*. Based on Adam mtDNA heritage, observed only at the
puberty only in *born boy's* seminal liquid (not in vitro made), I have
developed a new bio-communication theory, Mitochondrial Adam DNA data
transmission theory - ISBN 978-606-92107-1-0:

Abstract: Brain
and soul storming - The necessary and sufficient processes to a well
function of the human body are meticulous arranged by specific organizational
cells, so called process biomanagers, using interconditioned procedures,
transmitted through three ways of communication: chemical or “protein channelâ€쳌,
electrical or “ion channelâ€쳌 and mitochondrial or “EMF wireless channelâ€쳌. The
third type is out of the visible and measurable spectrum and raises a new
challenge to the scientists. For this type of bio communication we bring a new
theoretical hypothesis, based on the managerial multidisciplinary analysis of a
cybernetic model proposed by us, by simulating the human body function with the
virtual computerized system based on the management of its total knowledge and
its perfect quality way of function. The main bricks used for this virtual
construction are: the brain, as main bioprocessor, and Eve mtDNA and Adam
mtDNA, as bio-antennas. This assembly of the total knowledge, build with “brain
reasoning, biological feeling, and unlimited soul feelingâ€쳌, is called by us
“main decision triangle, IQ-EQ-CQâ€쳌. The main principle of the management of the
total knowledge imposes us to not neglect any information produced by man
during the time, even if it seems creasy at the beginning. Because in the
natural fertilisation the spermatozoids are naturally equipped with the
paternal mtDNA (a veritable main bio-GPS), we consider that the paternal
mitochondria DNA have a very important role in the evolution of the human being
life quality and we have developed a new hypothesis, “Adam mtDNA theoryâ€쳌, in
addition to “Eve mtDNA theoryâ€쳌.

Keywords:
brain, mitochondria, maternal, paternal
 

Avatar of: alexandru

alexandru

Posts: 1457

March 9, 2012

*Altough I know my lyre is doomed to sound in vain

Around your fudden reason, soaked in the vices'
rain.*

(Depraved youths - Mihai Eminescu)

 

When the scientist will
recognize the Adam mtDNA theory then he will understand how the nature and
condition of the sternal marrow is essential in establishing the final
diagnosis of the disease and he will understand that *The word of God is alive
and active, sharper than any double-edged sword. It cuts all the way through,
to where soul and spirit meet, to where joints and marrow come together. It
judges the desires and thoughts of man's heart.* (Bible,
Paul, Hebrew 4.12)

 

I have developed five years ago a new
theory on the paternal mitochondrial DNA inheritance that brings scientific
arguments and *new perspectives regarding the nature and origin of
biological information*. Based on Adam mtDNA heritage, observed only at the
puberty only in *born boy's* seminal liquid (not in vitro made), I have
developed a new bio-communication theory, Mitochondrial Adam DNA data
transmission theory - ISBN 978-606-92107-1-0:

Abstract: Brain
and soul storming - The necessary and sufficient processes to a well
function of the human body are meticulous arranged by specific organizational
cells, so called process biomanagers, using interconditioned procedures,
transmitted through three ways of communication: chemical or “protein channelâ€쳌,
electrical or “ion channelâ€쳌 and mitochondrial or “EMF wireless channelâ€쳌. The
third type is out of the visible and measurable spectrum and raises a new
challenge to the scientists. For this type of bio communication we bring a new
theoretical hypothesis, based on the managerial multidisciplinary analysis of a
cybernetic model proposed by us, by simulating the human body function with the
virtual computerized system based on the management of its total knowledge and
its perfect quality way of function. The main bricks used for this virtual
construction are: the brain, as main bioprocessor, and Eve mtDNA and Adam
mtDNA, as bio-antennas. This assembly of the total knowledge, build with “brain
reasoning, biological feeling, and unlimited soul feelingâ€쳌, is called by us
“main decision triangle, IQ-EQ-CQâ€쳌. The main principle of the management of the
total knowledge imposes us to not neglect any information produced by man
during the time, even if it seems creasy at the beginning. Because in the
natural fertilisation the spermatozoids are naturally equipped with the
paternal mtDNA (a veritable main bio-GPS), we consider that the paternal
mitochondria DNA have a very important role in the evolution of the human being
life quality and we have developed a new hypothesis, “Adam mtDNA theoryâ€쳌, in
addition to “Eve mtDNA theoryâ€쳌.

Keywords:
brain, mitochondria, maternal, paternal
 

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