Debate over RNA Transcription

Researchers question earlier findings of a new mechanism for gene regulation.

By | March 19, 2012

kyz" > Flickr, kyz

FLICKR, KYZ

Results regarding a new type of RNA editing, reported last July by Vivian Cheung at the University of Pennsylvania, were questioned last Thursday (March 15) by three groups publishing technical commentaries in Science.

Cheung’s research found more than 10,000 cases in which RNA underwent an additional editing step before being translated into protein, suggesting a possible rewrite of the central dogma, which states that the RNA message usually matches the original gene. The work was immediately criticized by biologists who questioned Cheung’s interpretation of her results.

Now, three independent research groups who reanalyzed Cheung’s data say that up to 94 percent of the reported RNA editing sites were inaccurately assessed.  They state that errors in sequencing, gene mapping, and genotyping, among others, led to an overestimation of RNA editing by an order of magnitude.  Cheung, however, stands by her work, reported Nature.

Add a Comment

Avatar of: You

You

Processing...
Processing...

Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo

Comments

Avatar of: Michael Holloway

Michael Holloway

Posts: 36

March 20, 2012

Who writes your headlines?  This has nothing to do with transcription or gene regulation.

Avatar of:

Posts: 0

March 20, 2012

Who writes your headlines?  This has nothing to do with transcription or gene regulation.

Popular Now

  1. Monsanto Buys Rights to CRISPR
    The Nutshell Monsanto Buys Rights to CRISPR

    The US agribusiness secures a global, nonexclusive licensing agreement from the Broad Institute to use the gene-editing technology for agricultural applications.

  2. How Plants Evolved Different Ways to Make Caffeine
  3. ESP on Trial
    Foundations ESP on Trial

    In the 1930s, parapsychologist Joseph Banks Rhine aimed to use scientific methods to confirm the existence of extrasensory perception, but faced criticisms of dubious analyses and irreproducible results.

  4. Another DNA Vaccine for Zika Shows Promise
RayBiotech