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Identifying Diet-Treatable Diseases

Scientists test which mutations underlie metabolic diseases that may benefit from changes in diet.

By | April 10, 2012

image: Identifying Diet-Treatable Diseases Clix | stock.xchng

CLIX / STOCK.XCHNG

Scientists have classified which alleles of a mutated enzyme can benefit from changes in diet, in a new yeast study published last week (April 1) in Genetics. Mutations in the cystathionine-ß-synthase (CBS) enzyme can lead to a variety of diseases, such as mental retardation and homocystinuria. Some patients benefit from supplementing their diet with vitamin B6, a cofactor that aids CBS’s enzymatic activity, but it depends on which mutation they carry.

To identify the CBS mutations whose resulting diseases could be aided by diet, scientists from the University of California, Berkeley, expressed different alleles of the human CBS gene in yeast that were missing the CBS ortholog Cys4p. They then measured yeast growth and enzyme activity with and without vitamin B6 or heme, another CBS cofactor.

The researchers were able to successfully sort alleles based on response to cofactor supplementation, which will help doctors identify which patients will respond well to early dietary interventions.

“This study moves us a step closer toward better understanding the genetic variability among people,” Mark Johnston, editor-in-chief of the journal Genetics, said in a press release. “More immediately, knowledge of these gene mutations will help physicians prescribe treatment based on genotype rather than outward symptoms or trial and error.”

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Comments

Avatar of: davidzholder

davidzholder

Posts: 1

April 11, 2012

We still need to feed our family healthy, well-balanced meals while keeping to a set budget. Change is the hardest thing and trying to do everything at once will have most people quitting before they even begin. You can get samples from sites like "Official Samples" where you can find all samples

Avatar of: Tom Hennessy

Tom Hennessy

Posts: 1457

April 11, 2012

Vitamin B6 is a well known iron chelator.
"Vitamin B6 promotes iron excretion and this has been used as a rationale for treatment in iron storage diseases"

In sickle cell , a genetic disease , they have shown iron reduction leads to a long term remission of their disease .
"Iron chelators hydroxyurea and bathophenanthroline"
"Oral liquid hydroxyurea promising for long-term use in babies with sickle cell anemia"
 
May? it be simply the fact the body is being targeted BY increased iron so WHEN one IS placed on an iron chelator the CAUSE is removed ?
JUST like this HSP70 is hypothesised to do and JUST like B6 is shown to do?
"Researchers at Fox Chase Cancer Center have demonstrated how it could be possible to treat genetic diseases by enhancing the natural ability of cells to restore their own mutant proteins."
"Proteosome inhibitors could provide one way of manipulating cells into producing more of a so-called chaperone protein, named Hsp70, which helps amino acid chains fold into their proper protein form."
http://www.sciencedaily.com/re...

"Autophagy of HSP70 and chelation of lysosomal iron in a non-redox-active form"
http://www.ncbi.nlm.nih.gov/pu...

Avatar of:

Posts: 0

April 11, 2012

We still need to feed our family healthy, well-balanced meals while keeping to a set budget. Change is the hardest thing and trying to do everything at once will have most people quitting before they even begin. You can get samples from sites like "Official Samples" where you can find all samples

Avatar of:

Posts: 0

April 11, 2012

Vitamin B6 is a well known iron chelator.
"Vitamin B6 promotes iron excretion and this has been used as a rationale for treatment in iron storage diseases"

In sickle cell , a genetic disease , they have shown iron reduction leads to a long term remission of their disease .
"Iron chelators hydroxyurea and bathophenanthroline"
"Oral liquid hydroxyurea promising for long-term use in babies with sickle cell anemia"
 
May? it be simply the fact the body is being targeted BY increased iron so WHEN one IS placed on an iron chelator the CAUSE is removed ?
JUST like this HSP70 is hypothesised to do and JUST like B6 is shown to do?
"Researchers at Fox Chase Cancer Center have demonstrated how it could be possible to treat genetic diseases by enhancing the natural ability of cells to restore their own mutant proteins."
"Proteosome inhibitors could provide one way of manipulating cells into producing more of a so-called chaperone protein, named Hsp70, which helps amino acid chains fold into their proper protein form."
http://www.sciencedaily.com/re...

"Autophagy of HSP70 and chelation of lysosomal iron in a non-redox-active form"
http://www.ncbi.nlm.nih.gov/pu...

Avatar of:

Posts: 0

June 30, 2012

i think this kind of diet might vary on different people with different condition, so it's hard to just list a sample diet list right?

Avatar of: Jocelyn ZHOU

Jocelyn ZHOU

Posts: 1457

June 30, 2012

i think this kind of diet might vary on different people with different condition, so it's hard to just list a sample diet list right?

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