An Antidote for Cocaine Overdose?

A novel antibody with a powerful affinity for cocaine shows promise in reversing the deadly effects of an overdose.

By | April 19, 2012

Flickr, WillWinter

FLICKR, WILLWINTER

A new anti-cocaine passive vaccine—a vaccine consisting of ready-made antibodies—can reverse the effects of acute toxicity following a lethal dose of the drug in mice, according to a study published last month in Molecular Pharmaceutics, a journal of the American Chemical Society. The vaccine, developed by chemist Kim Janda of The Scripps Research Institute and colleagues, consists of a human monoclonal antibody, dubbed GNCgzk, which binds to cocaine 10 times stronger than other anti-cocaine molecules reported in the literature. It was Janda who, in the mid-1990s, helped develop the first anti-cocaine vaccine. (See The Scientist’s 2011 feature on this topic, Shooting Down Addiction.)

The antibody candidate was isolated from a screen of more than 1,500 molecules and “has distinguished itself as a passive vaccine holding the greatest clinical promise,” the authors concluded in the Molecular Pharmaceutics paper.

Add a Comment

Avatar of: You

You

Processing...
Processing...

Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo

Comments

Avatar of: James B. Messer

James B. Messer

Posts: 2

June 3, 2012

From helping to reduce the immediate effects of overdose to preventing
relapse in addicts, this cocaine antidote could be a
practical life-saver for the future.
non-faith based rehabs

Avatar of:

Posts: 0

June 3, 2012

From helping to reduce the immediate effects of overdose to preventing
relapse in addicts, this cocaine antidote could be a
practical life-saver for the future.
non-faith based rehabs

Popular Now

  1. A Potential Remedy for the Aging Brain
    The Scientist A Potential Remedy for the Aging Brain

    In mice, injected fragments of a naturally occurring protein boost memory in young and old animals and improve cognition and mobility in a model of neurodegenerative disease. 

  2. The Sleeping Brain Can Learn
    Daily News The Sleeping Brain Can Learn

    Humans can remember new sensory information presented during REM sleep, but this ability is suppressed during deep, slow-wave slumber.

  3. USDA Emails: Don’t Use “Climate Change”
  4. Nature Index Identifies Top Contributors to Innovation
AAAS