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Camel Pharmacies?

Researchers create transgenic cells that may help camels produce milk full of therapeutic proteins.

By | June 4, 2012

image: Camel Pharmacies? WIKIMEDIA COMMONS, TOBY HUDSON

WIKIMEDIA COMMONS, TOBY HUDSON

Camels’ highly adaptable nature and resistance to disease has always made them essential to desert-dwelling cultures, and with a little help from genetic engineering they may one day provide us with cheaper drugs. A team of researchers at Dubai’s Camel Reproduction Centre have created transgenic camel embryos to which they introduced non-human genes "similar to those of humans," according to United Arab Emirates newspaper, The National. They haven’t yet been able to introduce human genes into the embryos, but the head of the Centre’s reproductive biology lab, Nisar Wani, told The National that he and his team have taken an important first step. If human genes that code for proteins such as insulin could be added, the camels could produce milk laden with pharmaceuticals to fight diabetes, obesity and emphysema.

"Patients with genetic disorders need these proteins, which are very costly today because companies are producing them by bacterial cultures in their labs," Dr Wani said. "But if we're successful at producing them in the milk, say in 15 to 30 litres, we can get a huge quantity of protein and that will drastically decrease their cost worldwide."

Wani’s group is currently working on increasing the ratio of implanted embryos that survive to delivery, and introducing new genes from other species to improve milk production. Increased lactation could bring the cost of milk-borne drugs down, but Wani cautions that mass-production is still at least five years off.

The Centre’s success with camels, including sequencing its genome and producing the first cloned camel in 2009, prompted Wani to predict that this new innovation could one day make camels ideal candidates for growing human organs for transplant.

"Soon we will have organs that will be like universal tools for anybody who has a kidney failure or heart problems," he said. "He can get the organ from the animal."

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Comments

Avatar of: 1969_73

1969_73

Posts: 3

June 5, 2012

Another naive idea. Why do you suppose similar approaches in cows, goats, and pigs haven't reached the market? Fear of retroviruses spreading to humans. Just because camels haven't been studied much, doesn't mean they don't have them. I would be surprised if we start to depend on Middle East milk as much as their oil!

Avatar of: FJScientist

FJScientist

Posts: 52

June 5, 2012

Ample prior work over the past decade has shown proof-of-principal in a number of animals. But commercialization has been limited to date with issues ranging from irritated utters (and other effects on animal welfare) to the public apprehensions about any genetic technologies to production concerns. If, for some reason, the camel works out where others have failed, so much the better. But the article doesn't present this history and therefore sounds overly optimistic, even naive of that prior work.

Upon searching if any such product is currently marketed, I came across this quite reasonable article from 2010, for those further interested.
http://triplehelixblog.com/201...

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