Protein biomarkers have been hailed as vital stepping stones in the race to personalize medicine. But many hurdles remain to be cleared before their application becomes routine. Currently, protein biomarkers have proven useful in drug discovery and development, as tools for target discovery and evaluation of a drug’s mechanism of action, and in therapies for prevention, early detection, diagnosis, and treatment of disease. Although single markers are in use, more widespread adoption will probably require a multiplexed panel capable of detecting and measuring biomarkers accurately, inexpensively, and easily in biological samples that are highly complex.
Before a biomarker can be put to use, it must undergo several stages of confirmation, validation, and qualification depending on its intended use. Sample preparation involves many challenges. Once an appropriate method has been chosen to isolate and measure the biomarker or pattern of markers, technical parameters of the assay must be defined to establish its sensitivity, specificity, reproducibility, and reliability.
This webinar, “Tackling the Challenges Involved with Protein Biomarkers,” brings together two experts who will discuss new approaches for dealing with everything from enriching the target protein molecule to methods now in use for isolating and detecting molecules, for biomarker discovery and applications. Following the presentations, the audience will have an opportunity to ask questions concerning their specific applications and receive answers in real-time.
Meet the Speakers
Dr. Katherine Williams is an assistant professor in the Department of Obstetrics, Gynecology, and Reproductive Sciences at the University of California, San Francisco, and is a senior member of the Sandler-Moore Mass Spectrometry Core Facility. Her research program is focused on using proteomics for biomarker discovery and verification in a wide range of human disease biology.
Dr. Lance Liotta is a tenured professor at George Mason University in the Department of Systems Biology, College of Science. He was one of the first scientists to investigate the process of tumor invasion and metastasis at the molecular level. Liotta has invented and patented technologies in the fields of diagnostics, nanotechnology (hydrogel nanoparticles for biomarker harvesting), microdissection (laser capture microdissection ) and proteomics (reverse-phase protein microarrays) that have been used to make broad discoveries in cancer biology and cancer therapy.