Stem Cell Trickery

A postdoctoral research fellow at Emory University falsifies stem cell research data.

By | July 9, 2012

image: Stem Cell Trickery Istockphoto

ISTOCKPHOTO

A former postdoc in the Department of Medicine at Emory University was found guilty of falsifying data presented at national and laboratory meetings, in ongoing and pending National Institutes of Health (NIH) grants, and in manuscripts submitted to five high-profile journals, according to a report by the Office of Research Integrity (ORI) published last Friday (July 6).

Sinae Kim, who joined the lab of Emory stem cell biologist Young-sup Yoon in 2008 after a 1-year stint as a postdoc at a university in Seoul, Korea, fudged immunocytochemistry images and real-time reverse transcription polymerase chain reaction (RT-PCR) results by using data she had obtained from her previous human embryonic stem cell (hESC) research in Korea to “confirm the generation, differentiation, and verification of human induced pluripotent stem cells (iPSCs),” the reported stated.

Among her transgressions, Kim shared mouse and human iPSC cell lines with some of her lab mates that had supposedly been generated from the peripheral blood of coronary artery disease patients, when in fact “she knew they were of other origin,” the report stated.

The falsified data affect 3 funded NIH grants, 5 NIH grant applications, 5 manuscripts submitted to Nature, Nature Medicine, Nature Biotechnology, Science, and Blood, and other documents.

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Avatar of: Bill

Bill

Posts: 1457

July 9, 2012

Big surprise.  Another foreigner faking data at a B-list university.

Avatar of: Shi V. Liu

Shi V. Liu

Posts: 1457

July 10, 2012

How can one (former) postdoc's (single-handed) falsifications affect so many (mentor's) grants, grant applications, manuscripts (to so many "top" journals), etc.?
When were those five manuscripts submitted to Nature, Nature Medicine, Nature Biotechnology, Science, and Blood? What were the reviewers and editors’ impressions on these manuscripts before the exposure of the misconduct?  What measures can be really effective to prevent this and eliminate this?

Avatar of: pottlebaby

pottlebaby

Posts: 1

July 11, 2012

11 Jul 2012 (07: 47: 56)

A British pharmaceutical company is developing a medicine against diabetes and its symptoms, such as cardiovascular diseases and obesity based on marijuana.

The company GW Pharmaceuticals researchers have revealed that two components of the famous drug, Tetrahydrocannabivarin (THCV) and cannabidiol, treatable diabetes of the second type because they can reduce the level of cholesterol in the blood and fat in organs, as, for example, in the liver.

Although it is known that cannabis produces a sensation of hunger when you smoke, these two components have the opposite effect: decreases appetite and protect the cells that produce insulin, making them work better.

Currently doctors carried out experiments with about two hundred patients and expect that the findings of the study are available at the end of this year.

"The effect on the rats was promising, components have improved metabolism of animals." Now we want to see how the new medicine influence human. "People use cannabis since hundreds of years ago why have much experience with this plant", said Stephen Wright, one of the authors of the study.

GW Pharmaceuticals is licensed for marijuana cultivation in greenhouses in southern England, although its exact location is kept a secret.

Source:
RT.com11 Jul 2012 (07: 47: 56)A British pharmaceutical company is developing a medicine against diabetes and its symptoms, such as cardiovascular diseases and obesity based on marijuana.The company GW Pharmaceuticals researchers have revealed that two components of the famous drug, Tetrahydrocannabivarin (THCV) and cannabidiol, treatable diabetes of the second type because they can reduce the level of cholesterol in the blood and fat in organs, as, for example, in the liver.Although it is known that cannabis produces a sensation of hunger when you smoke, these two components have the opposite effect: decreases appetite and protect the cells that produce insulin, making them work better.Currently doctors carried out experiments with about two hundred patients and expect that the findings of the study are available at the end of this year."The effect on the rats was promising, components have improved metabolism of animals." Now we want to see how the new medicine influence human. "People use cannabis since hundreds of years ago why have much experience with this plant", said Stephen Wright, one of the authors of the study.GW Pharmaceuticals is licensed for marijuana cultivation in greenhouses in southern England, although its exact location is kept a secret.Source:RT.com

Avatar of: sknman

sknman

Posts: 1

July 11, 2012

In large , active research labs, often the persuit of research takes on an " assembly line" mentality- when a post Doc or ' expert" technician does his/ her part for an array of experiments, and another group of post-Docs plan ( or execute) resarch projects that are related to the main theme ( eg.Stem cells), assembling parts of the puzzle created by many ' expert technicians'. In such an assebbly line activity, the defective piece made by the fraudster affects several manuscripts and grants.

Avatar of: Argiro_Ino

Argiro_Ino

Posts: 3

July 19, 2012

Plus, I thought science was free of prejudice, racism etc but obviously......

Avatar of: Argiro_Ino

Argiro_Ino

Posts: 3

July 19, 2012

You are missing the point.....science NOT nationality......

Avatar of: Bill

Bill

Posts: 1457

July 20, 2012

 Actually I'm not.  Seems like the overwhelming majority of fabrications are perpetrated by foreigners.

Avatar of: ELM

ELM

Posts: 2

November 14, 2012

Not that surprising. This is a hot area and the pressure to advance is very high. We definitely need new ways to determine or prevent the modification of images derived from experimental research.

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