Tissue on Chips Galore

The National Institutes of Health will fund 17 projects developing lab-on-a-chip applications to improve drug screening.

By | July 26, 2012

image: Tissue on Chips Galore nerve cell on a chipFlickr, Peter Fromherz via IsaacMao

The new National Center for Advancing Translational Sciences at the National Institutes of Health will oversee $70 million in grants over 5 years to help develop tissue-chip culture systems for drug screening.  The hope is that by incorporating multiple human cell types, these systems will be more predictive than animal models, which fail to predict human toxicity in approximately 30 percent of drugs tested.

Ten of the awards will go to the development of chips representing different organ systems such as the lung, liver, heart, and even brain.  The remaining seven are reserved for developing organ and tissues systems from stem cells and progenitor cells that are then differentiated into the desired tissue. This strategy has the added benefit of developing tissue with the appropriate architecture.

Many of the projects will aim to mimic not only an organ system, but also a disease state that can affect that organ, such as cardiovascular disease, cancer, arthritis, and gastrointestinal disease. (Hat tip to GenomeWeb.)



Add a Comment

Avatar of: You



Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo


Avatar of: Ray Greek

Ray Greek

Posts: 1

July 27, 2012

The 30% figure cited is based on the Olson study of 2000. It is fallacious as I explain at:
The Scientist should know better.


Popular Now

  1. Sex Differences in the Brain
    Features Sex Differences in the Brain

    How male and female brains diverge is a hotly debated topic, but the study of model organisms points to differences that cannot be ignored.

  2. DNA Repair Pioneers Win Nobel
    Daily News DNA Repair Pioneers Win Nobel

    Tomas Lindahl, Paul Modrich, and Aziz Sancar have won this year’s Nobel Prize in Chemistry for their work elucidating mechanisms of DNA repair.

  3. Antiparasite Drug Developers Win Nobel
    Daily News Antiparasite Drug Developers Win Nobel

    William Campbell, Satoshi Omura, and Youyou Tu have won this year’s Nobel Prize in Physiology or Medicine in recognition of their contributions to antiparasitic drug development.

  4. Brain Gain
    Features Brain Gain

    Young neurons in the adult human brain are likely critical to its function.

Logos Biosystems
Logos Biosystems
Life Technologies