Monkey Brain Booster

Scientists use a frontal-lobe implant to improve thinking skills in primates.

By | September 19, 2012

image: Monkey Brain Booster

Researchers at Wake Forest Baptist Medical Center and the University of Southern California improved thinking and restored decision-making in five monkeys using an electrode array implanted into their prefrontal cortex—the area of the brain responsible for planning and decision-making.

In the study, published last week (September 13) in The Journal of Neural Engineering, researchers probed the monkey’s cerebral cortex in order to map neuron activity as they played an image matching game, which they learned to play with 75 percent accuracy. In the game, monkeys were presented with an image—of either a person, a toy, or mountains—that they would have to identify a few moments later from a collection of images. If they identified the image correctly, they would get a treat as researchers took note of which neurons had fired.

After the researchers mapped the neural pathway that led to a correct answer, they inserted a stimulator into the monkey’s brains that could trigger that pathway. They then impaired the monkey’s cognitive abilities by giving them cocaine—which caused their scores to go down 20 percent—and restored their performance by triggering the mapped neural pathway with the stimulator. When the researchers repeated the experiment without the drug impairment, they found that monkeys scored higher than their 75 percent average.

“When you turn on the stimulator, they don’t make those errors; in fact, they do a little better than normal,” Wake Forest’s Robert E. Hampson, lead author of the study, told The New York Times.

Though the technology is years away from commercialization, the success of the brain prosthesis in the monkeys—which have a similar brain structure to humans—could fuel efforts to restore cognitive ability in people with brain damage.

Add a Comment

Avatar of: You



Sign In with your LabX Media Group Passport to leave a comment

Not a member? Register Now!

LabX Media Group Passport Logo


Avatar of: EllenHunt


Posts: 74

September 19, 2012

A long, long, long way off. The stimulator can improve performance for one task. If the same stimulation improved performance for any cognitive task I'd be impressed.

Avatar of: steinp2


Posts: 33

September 20, 2012

Like the experiment, the only way to improve would be to know what is going on pre- and post-insult. Hence, in order to "restore cognitive ability in people with brain damage", one would need to map out every response to every choice under every possible condition in life and store it forever waiting to be used in case some sort of disease process comes along down the line. [Insert your choice of derogatory statement here.]

Paul Stein

Popular Now

  1. The Mycobiome
    Features The Mycobiome

    The largely overlooked resident fungal community plays a critical role in human health and disease.

  2. Antibody Alternatives
    Features Antibody Alternatives

    Nucleic acid aptamers and protein scaffolds could change the way researchers study biological processes and treat disease.

  3. Circadian Clock and Aging
    Daily News Circadian Clock and Aging

    Whether a critical circadian clock gene is deleted before or after birth impacts the observed aging-related effects in mice.

  4. Holding Their Ground
    Features Holding Their Ground

    To protect the global food supply, scientists want to understand—and enhance—plants’ natural resistance to pathogens.

Life Technologies