The Epigenetic Lnc

Long non-protein-coding RNA (lncRNA) sequences are often transcribed from the opposite, or antisense, strand of a protein coding gene. In the past few years, research has shown that these lncRNAs play a number of regulatory roles in the cell. For exa

By | October 1, 2012

image: The Epigenetic Lnc Infographic: The Epigenetic Lnc
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Long non-protein-coding RNA (lncRNA) sequences are often transcribed from the opposite, or antisense, strand of a protein coding gene. In the past few years, research has shown that these lncRNAs play a number of regulatory roles in the cell. For example, after they are transcribed (pictured here) lncRNAs can direct epigenetic modification by becoming associated with methyltransferases—enzymes that mark DNA or histones with methyl groups—and bringing those enzymes to specific areas in the genome. Where the lncRNA binds is determined by the nucleic acid’s sequence and folding conformation.

Read "Lamarck and the Missing Lnc"


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Avatar of: jvkohl


Posts: 53

October 1, 2012

At some point, which is not a point of random mutation, epigenetic effects of nutrient chemicals and pheromones on intracellular signaling and stochastic gene expression must result in genetically predisposed behavior that may be transgenerationally inherited and again epigenetically effected (or not) by an organism's sensory environment. The requirement for sensory cause and unconscious behavioral affect is met via epigenetic effects of nutrient chemicals and via pheromones that control reproduction and ecological, social, neurogenic, and socio-cognitive niche construction. The requirement for sensory cause and behavioral affect cannot be met by random mutations because random mutations do not typically result in benefits to an organism's survival or to the survival of any species that could be compared to the benefits of food and reproduction. Does everyone who is not an evolutionary theorist understand that?

Kohl, J.V. (2012) Human pheromones and food odors: epigenetic influences on the socioaffective nature of evolved behaviors. Socioaffective Neuroscience & Psychology, 2: 17338.

Avatar of: wzpwlsbio


Posts: 5

October 22, 2012

you are right!  the eoigenetics  recorder the course of development and its changes. When the variants accumulate  and add to a peak,a new snp will come out to fix the epigenetics.

my email:


Avatar of: James V. Kohl

James V. Kohl

Posts: 336

October 23, 2012

Thanks. Is this generally known? I would like to find an article that reviews or summarizes the process of intermolecular changes in DNA that appear to be driven by dysregulation of the microRNA / messenger RNA balance. When I asked about this after a presentation at SFN in New Orleans (last week), I got the impression that the molecular mechanisms involved were known and accepted, but the degree of specialization required to understand homeostasis at this level is extreme. Perhaps the problem lies in the inability to explain the mechanisms to anyone outside the specialty.

my email;

Avatar of: Hugh-F-61


Posts: 67

October 23, 2012

You might like to know that the fungus gnat, Sciara coprophilia, throws out whole chromosomes during its life cycle. The germ line separates from soma before the 6th. cell division. Somatic cells then lose all the limited (L) chromosomes. They fail to separate and are left behind when the cells divide. Female soma throw out one X chromosome of paternal origin, the male somatic cells throw out both of them. Some L chromosomes are lost from germline cells. At  meiosis in spermiogenesis both divisions are unequal and all the normal autosomal chromosomes (a)  and X chromosome of paternal origin are lost, so the sperm carries a set of chromosomes identical to those inherited in the egg. Female meiosis is relatively normal, but the number of L chromosomes in the gametes may vary. It is pretty clear that the chromosomes in the sperm carry different epigenetic marking from the egg chromosomes, and the cells use this to identify them for elimination (Mtez, 1938, American naturalist 72, pages 485-520). Other flies, scale insects and mealy bugs do similar chromosome eliminations.

Avatar of: James V. Kohl

James V. Kohl

Posts: 336

October 24, 2012

Thanks. I'd like to stay more in the realm of what's known from the honeybee model organism in the context of changes in nutrient chemicals that result in changes in the queen's pheormones that appear to epigenetically alter the brain and behavior in members of different castes.

It's easier to use the honeybee to extend the concept of epigenetic tweaking of immense gene networks and adaptive evolution across species via olfaction and odor receptors. I tend to get lost with the addition of too many species differences that cannot be directly linked (e.g., epigenetically) to nutrient chemical dependent behavior and pheromone-controlled reproduction.


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