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Immune System Kills Cancer

T-cells engineered to attack B-cells sent adults’ acute leukemia into remission.

By | March 27, 2013

WIKIMEDIA, VASHIDONSKGene therapy has rid three adult patients of acute leukemia. The patients have been cancer-free for 5 months to 2 years, according to a study published last week (March 20) in Science Translational Medicine. Two other patients received the therapy, but one died for reasons believed to be unrelated, and the second died after relapsing.

“We had hoped, but couldn’t have predicted that the response would be so profound and rapid,” Renier Brentjens, lead author of the paper and an oncologist at Memorial Sloan-Kettering Cancer Center, told The New York Times.

The patients all had B-cell acute lymphoblastic leukemia and had relapsed following chemotherapy. The outlook for patients in this category is typically bleak.

The researchers filtered the patients’ blood for T-cells and engineered them with a virus carrying genetic material that would make them recognize CD19, a protein expressed on the surfaces of B-cells. When put back into the patients, the T-cells were meant to attack the B-cells, whether cancerous or normal. The patients experienced unpleasant and dangerous immune reactions, but four of them, including the one that eventually died of an unrelated blood clot, went into remission.

The four patients who went into remission also received bone marrow transplants following the therapy, although it is unclear whether the transplants contributed to their recovery.

This is the first time T-cell therapy has been used successfully to treat adults with acute lymphoblastic leukemia. Another treatment based on training T cells to attack cancerous cells is being developed at the University of Pennsylvania and is being used to treat childhood leukemia and chronic leukemia in adults.

The Sloan-Kettering approach for treating B-cell acute lymphoblastic leukemia will be tested in a second trial of 50 patients, New Scientist reported. The same idea could also be used to treat other cancers.

“Although it's early days for these trials, the approach of modifying a patient's T-cells to attack their cancer is looking increasingly like one that will, in time, have a place alongside more traditional treatments," Paul Moss, a cancer researcher at the University of Birmingham, told New Scientist.

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Avatar of: Alexandru

Alexandru

Posts: 71

March 31, 2013

Motto: Happy Easter!

Let this joy of Easter fill up our heart,

Today and the whole year ahead.

May you live a long life and

May Easter come in your life 100 times.

 

Thanks! This is a very interesting article!

According to the medicine researches, the cells cancer is the result of the spindle pole body misorientation. Let me start with some scientific conclusion about the necessity of the scientific discoveries:

"What is it that breathes fire into the equations and makes a universe for them to describe? ... Then we shall all, philosophers, scientists, and just ordinary people, be able to take part in the discussion of the question of why it is that the universe and we exist. If we find the answer to that, it would be the ultimate triumph of human reason - for then we would know the mind of God. " (Stephen Hawking - A Brief History of Time, From Big Bang to Black Holes)

Henry Schaefer - "The significance and joy in my science comes in the occasional moments of discovering something new and saying to myself, 'So that's how God did it!' My goal is to understand a little corner of God's plan." (U.S. News & World Report, Dec. 23, 1991)

Moreover, in addition, philosophical one and biblical one:

"The bad part is that people of medicine dealing with the body more than soul." (Lev Tolstoy - Last year's journal / About God and man)

"Foolish people! How long do you want to be foolish? How long will you enjoy pouring scorn on knowledge? Will you never learn? Listen when I reprimand you; I will give you good advice and share my knowledge with you." (The book of Solomon proverbs 1. 22-23)

..................

Now is the Catholic Easter and even the scientists are sceptics I ask you to give me the permission to explain an orthodox- scientific similitude discovery, because the Bible accept the physical anthropology evolution and in the spiritual evolution too (Daniel 7.4 - "The first was like a lion with the wings of an eagle. As I watched, its wings were pulled off. Then it was lifted to an upright position and made to stand on two feet, just like a human, and it was given a human heart.")

In medicine "sternum" is called "double-edged sword".

In Hellenic, "xiphos" means the "pinpoint". (sharper).

Bible, Paul, Hebrew 4.12: "The word of God is alive and active, sharper than any double-edged sword. It cuts all the way through, to where soul and spirit meet, to where joints and marrow come together. It judges the desires and thoughts of man's heart. There is nothing that can be hidden from God; everything in all creation is exposed and lies open before his eyes. And it is to him that we must all give an account of ourselves."

Bible, Paul, 2 Corinthians 3.3 - "Being revealed that you are a letter of Christ, served by us, written not with ink, but with the Spirit of the living God; not in tablets of stone, but in tablets that are hearts of flesh."

Bible, Ezekiel 11.19 - "I will give you a new heart and put a new spirit in you; I will remove from you your heart of stone and give you a heart of flesh."

Bible, Genesis 9.4 - "I forbid this because the life is in the blood."

 

Because the paternal mitochondria reappear at puberty in the naturally born boy's sperm, and not in vitro made, my discovery is based on Adam mtDNA inheritance.

To harmonize the proportion and the function of the body we shall use the combination of Eve mtDNA with Adam mtDNA existed only in xifoid process. "This is what the parable means: the seed is the word of God." (Luke 8.11) and "So they are no longer two, but one. Man must not separate, than, what God has joined together." (Matthew 19.6)

 

My observation - "as traditional treatments", the transplants of bone marrow shall follow the word therapy too in accordance with Matthew 4.4: "Man cannot live on bread alone, but needs every word that God speak."

 

Epilogue: "The same idea could also be used to treat other cancers." (from article)

 

see also:

http://www.the-scientist.com//?articles.view/articleNo/34108/title/Immune-to-Failure/

http://www.the-scientist.com/?articles.view/articleNo/34482/title/Synthetic-Peptide-Fools-Immune-System/

http://www.the-scientist.com/?articles.view/articleNo/34376/title/Relationship-Stress-May-Lower-Immunity/

 

Avatar of: Misha

Misha

Posts: 1

April 1, 2013

@Alexandru, what does the bible have to do with any of this?

Avatar of: Alexandru

Alexandru

Posts: 71

April 1, 2013

Dear Misha,

For me it is necessary to explain and not enough to belief.

Excuses me but I use other biblical word for this request: "We honor God for what He conceals; we honor kings for what they explain!" (Proverbs 25.2)

Because the paternal mitochondria reappear, logically - not mysterious, at the puberty only in the sperm of the naturally borne boys and not in vitro made, I suppose that you agree the inheritance theory of Adam mtDNA.

Do not forget that Adam mtDNA is not use during in vitro fertilisation.

What a big mistake! Geneticists separate Adam and Eve....

The only information that drives me to found the Adam mtDNA in xiphoid process is Paul, Hebrew 4.12.

In medicine, sternum is called double-edged sword.

In Hellenic, xiphos means the pinpoint (sharper).

The sternum marrow produces the figurative elements necessary for blood regeneration.

Remember that in the organs produced with stem cells cancer reappears after 40-45 days from implant (Yukiko Yamashita, University of Michigan - First EMBO Conference on Centrosomes and Spindle Pole Bodies, 12-16 September 2008 Heidelberg, Germany)

The known bio-magnetic sensors are Eve mtDNA, existed in all cells but not in blood, that looks like a log periodic antennas - 30-300 MHz (aura or human energy field) - for wireless communication with another living body, with the Universe or with the Nature.

Other bio-magnetic sensors is Adam mtDNA that looks like a nine spirals broadband quantum cascade laser and I calculate a 33 THz resonance frequency - difficult to measure.

Mixing this information, God or Allah, it doesn-t matter, can communicate with any living body only if the body is equipped with bio-magnetic sensors.

That is why the Bible specifying: God communicates only with Adam (Adam mtDNA - called life-giving spirit - that memorise all the body information).

After all, it is your choice to search or not the rationality of this information.

Avatar of: Metafysik

Metafysik

Posts: 1

April 2, 2013

 

@Alexandru


I had a bit of difficulty understanding some of your argument because of your fragmented english, where are you from? 


Anyways, what you say is interesting, but you appear misinformed on some things. Also, I am a Christian agnostic and a natural philosopher.

Most importantly, what is Adam mtDNA? If you are referring to paternal mitochondrial DNA, then you should know that in humans, only one reported case of paternally inherited mtDNA has ever been documented. This man had paternal mtDNA recombinants located only in his muscle tissue and it caused excessive production of lactic acid during excercise, resulting in being unable to stress his muscles for more than a few seconds. 

http://en.wikipedia.org/wiki/Paternal_mtDNA_transmission - Please Read


Paternal mtDNA inheritance in humans is hardly even possible, for a good reason. As for the lack of appearance of paternal mitochondrial DNA in sperm during puberty for in vitro males,  I would be interested in reading more on this. What is your source? 

Despite the in vitro male's lack of parental mtDNA in sperm, it shouldn't matter anyways because paternal mtDNA in sperm is destroyed during fertiliziation (thus is not inherited). Adam mtDNA does not exist because paternal mtDNA almost never gets inherited! Thus, mtDNA can not be traced back to Adam! It can only be traced back to Eve! 

However there is such a thing as the Y-Chromosomal Adam, but that is unrelated.

 

Besides that, you make some large explanatory gaps in your logic. 

For Example:

The bio-magnetic sensors  that exist within mitochondrial eve that you speak of, how do you know that they transmit/recieve frequencies between 30 and 300 MHz? What are they transmitting? If they are transmitting magnetic pulses how would they be received by anything other than neighboring cells? The force of magnetism within a cell would be substantially weak and unable to "Communicate" with Eve cells living cells outside of its body. 

Even if this communication could occur, what is your evidence that this frequency spectrum of magnetism is used to communicate with other living things, "The Universe" and/or God? This seems to be wild speculation. Sorry, but the notion that this "aura" generated by the combined magnetism of our cells is capable of long range "wireless" transmission is also speculation. 

As for your claim that Adam mtDNA has different sensors, well I already mentioned that it doesn't exist, but lets say there are unique sensors in paternal mtDNA. What does it matter if they would only exist within "natural born" sperm and are destroyed upon fertilization 99.999% of the time in humans?

You don't make it clear how this cell communication relates to bone marrow transplants either.

I also really don't understand your point when you parallel the sternum marrow and xiphos with those passages from the bible, could you elaborate what its significance is to your theory?

Lastly, you appear to claim that in vitros are incapable of communication with God or at least as having a spiritual disconnection as a result of their lack of parental mitochondrial dna. While I don't understand what the significance of not having paternal mitochondrial dna within in vitro male sperm cells, I find it  illogical that you claim this somehow prevents them from receiving God's word. According to you, their Eve mtDNA can still allow them to communicate with God. Besides that, I don't agree with your theory at all and claiming that these in vitros are spiritually isolated because of this is flawed theory is completley unjustified.

You also said that Adam mtDNA is not used during in vitro fertilization. It isn't "used" in natural fertilization either. Paternal mtDNA is destroyed during "natural" fertilization and I would assume the same occurs during in vitro, although I may be wrong in that. Please link a source for this claim that paternal DNA is not formed in in vtiro male sperm, I would be most interested to read it.

Also you claim that the xiphoid process somehow makes recombinants of Eve mtDNA and Adam mtDNA. What does the xiphoid process have anything to do with genetic manipulation?

We can't explain the existance of our own conscioussness, let alone explain the metaphysical dynamics of our relationship with God or our spiritual relationship with the universe so I don't beleive you can physically explain these dynamics through scientific observations.

While I appreciate to see a christian attempting to relate biological phenomena to the bible, I beleive you are attempting it illogically. 

But I like what you said about the Bible being compatible with anthropology and evolution, I agree.

You're making several factual errors and overall your argument is incoherent and not well-structured. I realize some of this may be due to your English limitations. I would be interested in hearing what you have to respond to my criticisms.

Avatar of: Alexandru

Alexandru

Posts: 71

April 3, 2013

Dear Metafysik,

Thanks for your comment. I appreciate your criticism too because few people spent time to speak with me on this subject.

Thanks to The Scientist that give us the permission to speak with the open eyes about unknown secrets of life on this site.

You agree only Eve mtDNA theory and your position is absolutely normal because you use only official information.

Please just read - Q&A: Male infertility expert answers your questions - and there are hundred like this: http://www.msnbc.msn.com/id/26680088/

I just extract a part of the article: - We are helping men to have a baby, but we don’t know why they don’t make sperm, said. Dr. Pasquale Patrizio, director of the Yale Fertility Center.

……………

Excuse me for my English. I come from Romania and I learned English alone. I am 63 years old and until 2006 I never read Genetic or/and Genesis, but in seven years I accumulated alone the necessary and sufficient data to make logical speculations.

As engineer, specialized in space communication and in management of data transmission on magnetic fields, I was surprised in 2006 when my son, student in medicine, comes to me with the sperm diagram that for him looks like microphone and for me looks like reflex klystron, an electronic device used in special communication on very high frequency.

Because I said that not Eve was created from one of Adam’s ribs, the Romanian theologians call me – unrequited and unconfessioned.

Because I said that Eve mtDNA is a copy of Adam mtDNA existed only in xiphoid process in one exemplar the Romanian scientists call me - schizoid and paranoid.

If somebody give me a rationally answer to this question I am sure that I loose my maladies: who get back in the sperm of the natural born boys, not in vitro made, the paternal mitochondria at the puberty? HOLLY SPIRIT, HAZARD or the PERFECT CREATION?

Because nobody answer, as expert in the total knowledge, I speculate that the paternal mitochondria, that give sperm motility, are surely passed down via father and I developed six years ago "the inheritance of father mitochondria theory" that GENETICALLY confirm GENESIS: Mitochondrial Adam DNA data transmissions theory - ISBN 978-606-92107-1-0

Patiently waiting for the geneticists wake up to see what they have been build, as Adam do during Eve creation, I come back to the Bible: ‘The stone that the GENOME builders rejected has become the very head of the corner”. (1 Peter 2.7)

I give you my contact address for direct communication: cosciua@yahoo.co.uk

Avatar of: Alexandru

Alexandru

Posts: 71

April 3, 2013

By the way, I have been worked in medical devices for five years. Two years ago I practically demonstrate to the medical specialists in magnetic resonance medical devices that I have the capacity to transmit insufficient data to the device necessary for a good analyze. Analyzing data they said that I have some maladies, even I feel better and I never used the medical drugs in the last ten years.

Avatar of: cw

cw

Posts: 1

April 4, 2013

The problem seems to me that when you transfuse cells  (say bone marrow) you don't pick and choose which ones are helpful and which will harm.  It is possible to take the harmful cells out as well as the parts of the cells that cause  damage or rejection.  I wish chemo was done in a petri dish instead of to a body.

Avatar of: Effe Bense

Effe Bense

Posts: 1

April 7, 2013

Alexandru, I really enjoy reading your comments. You know scientists only analyse the material world not being aware that the spiritual world is just the other half and the real source of the materia. 

Have a nice day! Effe

Avatar of: shamcco

shamcco

Posts: 1

April 15, 2013

Metafysic:  thank you for the information, it was interesting and accurate.

Alexandru:  you cannot use references that are not critically appraised, msnb is not a reference in any realm of the scientific world.  When you select information you have to assess the specialty and experience of the authors, sample size, experimental design and other things.  I don't think this is the right forum for you, but I encourage you to look for other blogs where you can find peers.

Effe:  thanks for nothing, your comment is borderline moronic.

With that said, I find that these types of experiments contribute even if the outcome is not parallel with the original hypothesis.  Maybe another (knowledgeable) scientist will apply this technique for other diseases.  It is also important to recognize that these are 'preliminary' results as the next phase include 50 patients only.  So, from my end, fingers crossed!

 

Avatar of: Alexandru

Alexandru

Posts: 71

April 28, 2013

shamcco - Thank you for your normal critics!

I appreciate all the geneticists' efforts to understand the human genome and the human microbiome and I do not want do disturb them. In accordance with European no frontier knowledge programme FP7, I just want to give a little help in a very-very new and unknown domain of the knowledge: wireless bio communication.

In my opinion, it is unreasonable to say that only maternal mitochondria Eve mtDNA are inherited as long as paternal mitochondria Adam mtDNA come back in the sperm at the puberty. Because these I consider incomplete the theory of Eve mtDNA inheritance, and I get into the scientific analyses the new theory about Adam mtDNA inheritance.

I do not impose it! I just wait for logical feedback!

For the theory I use all the information produced by humanity and I did only theoretical research (see brainstorming methods), but the purest certification of my words is the difference between the sperm of the natural borne boys and in vitro made boys.

see: http://www.msnbc.msn.com/id/26680088/

In addition, see other articles about the infertility of the in vitro made boys based on missing sperm or no sperm motility.

Speaking scientifically about magnetic parallel universe of the human soul, I just invite the scientific world to make a biological extension of the study in the xiphoid process to look for mitochondrial Adam and Eve divine couple.

However, using this research extension I am sure that it is possible to disturb the artificial fertilization technology!

Avatar of: N Lakshmidevi

N Lakshmidevi

Posts: 1

May 16, 2013

I like this site and it is  informative and also I am teaching immunology and medical microbiology  to post graduate students

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